Electrospun nanofibrous CMC/PEO as a part of an effective pain-relieving wound dressing
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A novel two-layered pain-relieving wound dressing was prepared from a combination of biocompatible polymers: carboxymethylcellulose and polyethyleneoxide, and two types of pain-relieving drugs: the non-steroid anti-inflammatory diclofenac and the local anesthetic lidocaine. To achieve the two-layered structure, electrospinning and impregnation of a commercially available wound dressing Aquacel® were used for preparation of respective layers. The electrospun nanofibers have been shown to possess similar features as found in the extracellular matrix, an important component of the skin. This characteristic could significantly contribute to the efficiency of wound healing. The second layer is based on Aquacel®, an important wound dressing in modern wound care. Since pain can drastically lower the wound healing process, as well as it is known to decrease the overall quality of patient life, pain-relieving drugs are very interesting for wound care applications. For efficient pain reduction, two types of drugs were used. When combined, these can cover different types of wound-related pain (due to the cause and treatment) and hence additionally aid the wound healing process. The combined features of the incorporated pain-relieving drugs and the mentioned materials are therefore very interesting for future studies toward clinical testing of possible prototype products.
KeywordsElectrospinning Nanofibers Aquacel® Wound dressing Pain Local anesthetic Lidocaine NSAID Diclofenac
The authors acknowledge the financial support from the Ministry of Higher Education, Science and Technology of the Republic of Slovenia, as well as the financial contributions from the WoodWisdom-NET+ funded project AEROWOOD with the Grant Number 3330-14-500041 and mnt-era.net funded project WoundSens with the Grant Number 3211-12-00002.
- 20.Petrulyte S (2008) Advanced textile materials and biopolymers in wound management. Dan Med Bull 55(1):72–77Google Scholar
- 24.Fogh K, Andersen MB, Bischoff-Mikkelsen M, Bause R, Zutt M, Schilling S, Schmutz J-L, Borbujo J, Jimenez JA, Cartier H, Jørgensen B (2012) Clinically relevant pain relief with an ibuprofen-releasing foam dressing: results from a randomized, controlled, double-blind clinical trial in exuding, painful venous leg ulcers. Wound Repair Regen 20(6):815–821CrossRefGoogle Scholar
- 27.Hanci V, Hakimoglu S, Ozacmak H, Bektas S, Ozacmak HS, Ozdamar SO, Yurtlu S, Turan IO (2012) Comparison of the effects of bupivacaine, lidocaine, and tramadol infiltration on wound healing in rats. Revista brasileira de anestesiologia 62(6):799–810Google Scholar
- 28.Kumarswamy A, Moretti A, Paquette D, Padilla R, Everett E, Nares S (2012) In vivo assessment of osseous wound healing using a novel bone putty containing lidocaine in the surgical management of tooth extractions. Int J Dent 894:815Google Scholar
- 30.Vowden K, Vowden P (2014) Wound dressings: principles and practice. Surgery 32(9):462–467Google Scholar
- 34.Tickle J (2012) Effective management of exudate with AQUACEL extra. Brit J Commu Nursing Suppl S38:S36–40Google Scholar
- 35.Manizate F, Fuller A, Gendics C, Lantis JC 2nd (2012) A prospective, single-center, nonblinded, comparative, postmarket clinical evaluation of a bovine-derived collagen with ionic silver dressing versus a carboxymethylcellulose and ionic silver dressing for the reduction of bioburden in variable-etiology, bilateral lower-extremity wounds. Adv Skin Wound Care 25(5):220–225CrossRefGoogle Scholar
- 49.Barnea Y, Weiss J, Gur E (2010) A review of the applications of the hydrofiber dressing with silver (Aquacel Ag) in wound care. Ther Clin Risk Manag 6:21–27Google Scholar
- 50.Harding K, Gottrup F, Jawien A, Mikosinski J, Twardowska-Saucha K, Kaczmarek S, Sopata M, Shearman C, Pieronne A, Kommala D (2012) A prospective, multi-centre, randomised, open label, parallel, comparative study to evaluate effects of AQUACEL(R) Ag and Urgotul(R) Silver dressing on healing of chronic venous leg ulcers. Int Wound J 9(3):285–294CrossRefGoogle Scholar
- 52.Zahedi P, Rezaeian I, Ranaei-Siadat S-O, Jafari S-H, Supaphol P (2010) A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polym Advan Technol 21(2):77–95Google Scholar