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Journal of Sol-Gel Science and Technology

, Volume 73, Issue 2, pp 501–505 | Cite as

Plasminogen activator entrapped within injectable alumina: a novel approach to thrombolysis treatment

  • Vasiliy V. Vinogradov
  • Alexander V. Vinogradov
  • Vladimir E. Sobolev
  • Ivan P. Dudanov
  • Vladimir V. Vinogradov
Brief Communication

Abstract

A major obstacle in the development of new enzyme-based thrombolytic systems is their low stability and extremely short half-life (usually, less than 2–6 min of circulation half-life), which requires their administration in large doses to obtain therapeutic effects, and as a consequence, inevitably leads to a significant incidence of hemorrhagic complications. Here we point to a potential solution of this problem by developing a new family of injectable composites for thrombolysis: plasminogen activator entrapped within alumina, where alumina is a pertinent drug carrier developed to prolong activity in vivo and to reduce the total administered dose of the drug necessary for the treatment, and hence its side effects.

Keywords

Sol–gel synthesis Plasminogen activator Thrombolytic effect Entrapment 

Supplementary material

10971_2014_3601_MOESM1_ESM.docx (697 kb)
Supplementary material 1 (DOCX 697 kb)

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Vasiliy V. Vinogradov
    • 1
  • Alexander V. Vinogradov
    • 1
  • Vladimir E. Sobolev
    • 1
  • Ivan P. Dudanov
    • 2
    • 3
  • Vladimir V. Vinogradov
    • 1
  1. 1.ITMO UniversitySt. PetersburgRussian Federation
  2. 2.Petrozavodsk State UniversityPetrozavodskRussian Federation
  3. 3.Regional Vascular CenterSt. PetersburgRussian Federation

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