Journal of Sol-Gel Science and Technology

, Volume 69, Issue 1, pp 9–16 | Cite as

Fabrication and characterization of dodecylamine derived monodispersed mesoporous bioactive glass sub-micron spheres

  • Qing Hu
  • Xiaofeng Chen
  • Naru Zhao
  • Yuli Li
  • Cong Mao
Original Paper
First Online:
Received:
Accepted:

Abstract

This paper reports a facile method for fabricating monodispersed mesoporous bioactive glass sub-micron spheres (MBGS) using dodecylamine (DDA) as a catalyst and template agent in sol–gel process. The effects of synthesis conditions including the amount of DDA, temperature of hydrolysis and the volume ratio of alcohol to water (AW ratio) on the resulting particle size, morphology, monodispersity and pore size distribution of MBGS are investigated and discussed. The results indicate that the particle size, morphology, monodispersity and pore size distribution of MBGS depend on the amount of DDA, the temperature of hydrolysis and the AW ratio. Meanwhile, using DDA as the structure directing agent and hydrolysis catalyst under optimal synthesis conditions (e.g. 4 g DDA, hydrolysis temperature at 40 °C and AW ratio at 4) is in favor of obtaining MBGS with mesoporous surface structure, large specific surface area (362.073 m2 g−1), relatively homogeneous particle size (~560 nm) as well as good apatite-forming activity. The unique structure and properties may turn MBGS into a good candidate as a drug delivery carrier or an injectable biomaterial for bone tissue regeneration.

Keywords

Sol–gel preparation Bioactive glass Monodispersed Mesoporous sub-micron spheres Apatite formation 
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Notes

Acknowledgments

This work was supported by the Key Project of the National Natural Science Foundation of China (Grant No. 50830101), National Natural Science Foundation of China (Grant No. 51072055, Grant No. 51172073, Grant No. 51202069), the National 973 project of China (2011CB606204), Research Fund for the Doctoral Program of Higher Education of China (20110172110002) and the Fundamental Research Funds for the Central University (2012ZP0001).

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Qing Hu
    • 1
    • 2
    • 3
  • Xiaofeng Chen
    • 1
    • 2
    • 3
  • Naru Zhao
    • 1
    • 2
    • 3
  • Yuli Li
    • 1
    • 2
    • 3
  • Cong Mao
    • 1
    • 2
    • 3
  1. 1.School of Materials Science and EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China
  2. 2.National Engineering Research Center for Tissue Restoration and ReconstructionGuangzhouPeople’s Republic of China
  3. 3.Guangdong Province Key Laboratory of Biomedical EngineeringSouth China University of TechnologyGuangzhouPeople’s Republic of China

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