Journal of Sol-Gel Science and Technology

, Volume 50, Issue 3, pp 421–429 | Cite as

Influence of mesoporous structure type on the controlled delivery of drugs: release of ibuprofen from MCM-48, SBA-15 and functionalized SBA-15

  • Isabel Izquierdo-Barba
  • Edesia Sousa
  • Juan Carlos Doadrio
  • Antonio Luis Doadrio
  • Joaquín Pérez Pariente
  • Africa Martínez
  • Florence Babonneau
  • María Vallet-RegíEmail author


Ordered mesoporous materials exhibit potential features to be used as controlled drug delivery systems, including their wide range of chemical compositions and their outstanding textural and structural properties. Therefore, it is possible to control the drug release kinetics by tailoring such parameters. In this paper, mesoporous materials such as MCM-48 and SBA-15, which present different pore sizes (3.7 and 8.8 nm) and structural characteristics (3D-bicontinuous cubic and 2D-hexagonal, respectively) have been synthesized to evaluate their application as drug delivery system and to determine their influence on release kinetic of ibuprofen. Moreover, a chemical modification of the SBA-15 mesoporous material with octadecyltrimethoxysilane has also been performed to study its influence on the release rate of ibuprofen. The structural characteristics (3D cubic and 2D hexagonal pore system) do not affect the release kinetic profiles of ibuprofen. On the contrary, the pore size affects highly to the release kinetic profiles from first-order kinetic to zero-order kinetic for MCM-48 and SBA-15, respectively. Moreover, the importance of surface functionalization was demonstrate through the very fast delivery of ibuprofen from SBA-15 mesoporous materials functionalized with octadecyl chains.


Ordered mesoporous materials Structural characteristics 2D-hexagonal 3D-bicontinuous cubic structure and functionalization 



Financial support of CICYT Spain, through research projects MAT2005-01486 and CAM S-0505/MAT/000324 is acknowledged.


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Copyright information

© Springer Science+Business Media, LLC 2009

Authors and Affiliations

  • Isabel Izquierdo-Barba
    • 1
    • 2
  • Edesia Sousa
    • 1
  • Juan Carlos Doadrio
    • 1
  • Antonio Luis Doadrio
    • 1
  • Joaquín Pérez Pariente
    • 1
  • Africa Martínez
    • 1
  • Florence Babonneau
    • 3
  • María Vallet-Regí
    • 1
    • 2
    Email author
  1. 1.Departamento de Química Inorgánica y Bioinorgánica, Facultad de FarmaciaUniversidad ComplutenseMadridSpain
  2. 2.Centro de Investigación Biomédica en Red, Bioingeniería, Biomateriales y Nanomedicina, CIBER-BBNMadridSpain
  3. 3.Chimie de la Matière Condensée de ParisUPMC-Paris6 and CNRSParisFrance

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