Journal of Sol-Gel Science and Technology

, Volume 45, Issue 1, pp 115–119 | Cite as

Sol–gel derived mesoporous bioactive glass fibers as tissue-engineering scaffolds

  • Jing Yi
  • Guangfeng Wei
  • Xiaohui Huang
  • Lingzhi Zhao
  • Quan Zhang
  • Chengzhong Yu
Original Paper


Mesoporous bioactive glass (MBG) fibers have been synthesized using the combination of a sol–gel process and a high velocity spray procedure by carefully controlling the sol composition, acidity and water content. A three-dimensional (3D) macro-structure with ∼50–100 μm interconnected macropores is formed in the spraying process. The MBG fibers possess well-ordered hexagonal mesostructure and excellent in vitro bioactivities. Sprague–Dawley (SD) rat osteoblasts have been cultured on MBG fibers. It is found that the MBG fibers have good cell biocompatibility and the 3D macro-structure is beneficial for cell attachment. It is anticipated that MBG fibers with controlled mesostructure and excellent in vitro bioactivity are good candidates for future tissue-engineering scaffolds.


Mesoporous Bioactive glass Sol–gel Fibers Tissue-engineering 



The authors thank the National Science Foundation of China (20573021, 30571877), Shanghai Science Committee (05DJ14005) and Shanghai Leading Academic Discipline Project (B113), the Ministry of Education of China (20060246010, FANEDD 200423) for financial supports.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jing Yi
    • 1
  • Guangfeng Wei
    • 1
  • Xiaohui Huang
    • 1
  • Lingzhi Zhao
    • 1
  • Quan Zhang
    • 2
  • Chengzhong Yu
    • 1
  1. 1.Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghaiP.R. China
  2. 2.Department of Orthopedics, Huashan HospitalFudan UniversityShanghaiP.R. China

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