Journal of Structural and Functional Genomics

, Volume 8, Issue 2–3, pp 121–140 | Cite as

Structural genomics of protein phosphatases

  • Steven C. Almo
  • Jeffrey B. Bonanno
  • J. Michael Sauder
  • Spencer Emtage
  • Teresa P. Dilorenzo
  • Vladimir Malashkevich
  • Steven R. Wasserman
  • S. Swaminathan
  • Subramaniam Eswaramoorthy
  • Rakhi Agarwal
  • Desigan Kumaran
  • Mahendra Madegowda
  • Sugadev Ragumani
  • Yury Patskovsky
  • Johnjeff Alvarado
  • Udupi A. Ramagopal
  • Joana Faber-Barata
  • Mark R. Chance
  • Andrej Sali
  • Andras Fiser
  • Zhong-yin Zhang
  • David S. Lawrence
  • Stephen K. Burley
Article

Abstract

The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.

Keywords

Structural genomics  Phosphatase  NYSGXRC X-ray crystallography 

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Steven C. Almo
    • 1
  • Jeffrey B. Bonanno
    • 1
  • J. Michael Sauder
    • 2
  • Spencer Emtage
    • 2
  • Teresa P. Dilorenzo
    • 1
  • Vladimir Malashkevich
    • 1
  • Steven R. Wasserman
    • 2
  • S. Swaminathan
    • 3
  • Subramaniam Eswaramoorthy
    • 3
  • Rakhi Agarwal
    • 3
  • Desigan Kumaran
    • 3
  • Mahendra Madegowda
    • 3
  • Sugadev Ragumani
    • 3
  • Yury Patskovsky
    • 1
  • Johnjeff Alvarado
    • 1
  • Udupi A. Ramagopal
    • 1
  • Joana Faber-Barata
    • 1
  • Mark R. Chance
    • 4
  • Andrej Sali
    • 5
  • Andras Fiser
    • 1
  • Zhong-yin Zhang
    • 6
  • David S. Lawrence
    • 7
  • Stephen K. Burley
    • 2
  1. 1.Albert Einstein College of MedicineBronxUSA
  2. 2.SGX Pharmaceuticals, Inc.San DiegoUSA
  3. 3.Brookhaven National LaboratoryUptonUSA
  4. 4.Case Western Reserve UniversityClevelandUSA
  5. 5.University of California at San FranciscoSan FranciscoUSA
  6. 6.Indiana University School of MedicineIndianapolisUSA
  7. 7.University of North Carolina at Chapel HillChapel HillUSA

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