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An automated synthesis method for 68Ga-labelled ubiquicidin 29–41

  • Jannie le RouxEmail author
  • Sietske Rubow
  • Thomas Ebenhan
  • Carl Wagener
Article
  • 15 Downloads

Abstract

Published methods for radiolabelling of 1,4,7-triazacyclononane-1,4,7-triacetic acid ubiquicidin (NOTA-UBI) 29–41 to date describe manual or kit-based procedures. The purpose of this study was to develop an automated synthesis method for the synthesis of [68Ga]Ga-NOTA-UBI. NOTA-UBI was successfully labelled with gallium-68 using three different automated procedures. The use of radical scavengers to improve radiochemical purity is also discussed. The automated procedures showed a high degree of robustness and repeatability. The validated automated synthesis protocols using a Scintomics GRP Module will contribute to provide GMP-compliant [68Ga]Ga-NOTA-UBI for clinical infection imaging.

Keywords

Automated synthesis Ubiquicidin NOTA-UBI 68Ga NOTA-UBI Good manufacturing practice Radiolabelling 

Notes

Acknowledgements

J le Roux has received financial assistance from Africa- X-ray Industrial and Medical (AXIM) in the form of a study bursary. The author would like to thank Janneke Rubow for assistance with the preparation of this manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Supplementary material

10967_2019_6910_MOESM1_ESM.docx (19 kb)
Supplementary material 1 (DOCX 19 kb)

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  1. 1.Division of Nuclear Medicine, Tygerberg HospitalStellenbosch UniversityTygerbergSouth Africa
  2. 2.Department of Nuclear MedicineUniversity of PretoriaPretoriaSouth Africa
  3. 3.RadiochemistrySouth African Nuclear Energy CorporationBritsSouth Africa

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