Analysis of radionuclide production in cyclotrons for application in positron emission tomography (PET)
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The present work focuses on the analysis of nuclear reactions that can occur in a cyclotron for the generation of radionuclides compliant with the restrictions necessary for medical use in a PET. These radionuclides ought to meet some features, such as being positron emitters and having a half-life as short as possible, considering the times of processing and administration of the radiopharmaceutical. The radionuclides studied, 61Cu, 64Cu and 68Ga, meet these conditions. A commercial cyclotron has been modelled with an energy of 18 MeV for protons. Several simulations have been carried out with the model, using different materials as a target. The model validation has been done comparing results with experimental data from the literature.
KeywordsNuclear reactions Cyclotron Monte Carlo Radiopharmaceuticals Positron emission tomography Production of radionuclides
Authors wish to thank professor Francisco Alves from Institute of Nuclear Sciences Applied to Health (ICNAS) of the University of Coimbra, Portugal, for his suggestions and help providing data to validate the developed model for MCNP.
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Conflict of interest
Authors declare that there is no conflict of interest.
- 7.Romero Sanz E (2017) Desarrollo de un generador de 68Ge/68 Ga. Aplicaciones del 68 Ga en tomografía por emisión de positrones. Univ. Complutense de Madrid, Madrid, SpainGoogle Scholar
- 8.International Atomic Energy Agency (2019) Gallium-68 cyclotron production, IAEA-TECDOC-1863. IAEA, ViennaGoogle Scholar
- 9.MCNP6 User’s Manual (2018) Code Version 6.1, Los Alamos National Laboratory, Los Alamos, New MexicoGoogle Scholar