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Journal of Radioanalytical and Nuclear Chemistry

, Volume 322, Issue 2, pp 1107–1113 | Cite as

High specific activity tritiation of various methylated histamine analogues

  • Crist N. FilerEmail author
  • Joseph R. Andrews
  • Ernest Do
  • C. T. Peng
Article

Abstract

It has been nearly 110 years since the discovery of histamine and its profound physiological actions as well as the four distinct binding sites that constitute its receptor family. Histamine agonists and antagonists when labelled with tritium have been very valuable in advancing our understanding of histamine receptors. Over the years, scores of histamine receptor ligands have been tritiated but few if any have been methylated derivatives of histamine. For that reason, this paper describes the tritiation of several methylated histamine analogues as well as their analytical characterization by HPLC, MS and tritium NMR.

Keywords

Histamine Methyl histamines Tritium Tritium NMR 

Notes

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  1. 1.PerkinElmer Health Sciences, Inc.WalthamUSA

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