Enzyme-responsive mechanism based on multi-walled carbon nanotubes and pectin complex tablets for oral colon-specific drug delivery system

  • Wenquan ZhuEmail author
  • Cuiyan Han
  • Yan Dong
  • Baiyu Jian


The purpose of this work was to explore the potential application of MCNT as a colon-specific delivery system based on the enzyme responsive mechanism. A novel type of enzyme-sensitive colon-specific tablet (PM-tablet) based on pectin and multi-walled carbon nanotube (MCNT) was prepared by wet granulation tabletting method. The PM-tablet in the presence of pectinase exhibited enzyme degradation release and achieve a precise release in the colon. Our study had proposed a novel idea for the application of MCNT on the oral colon-specific drug delivery system.


Multi-walled carbon nanotubes Colon Pectin Enyzme Tablet 



This work was supported by the Qiqihar Medical University research fund project (No. QY2016B-01).

Compliance with ethical standards

Conflict of interest

The authors report no conflicts of interest.

Supplementary material

10967_2019_6501_MOESM1_ESM.docx (425 kb)
Supplementary material 1 (DOCX 424 kb)


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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  1. 1.College of PharmacyQiqihar Medical UniversityQiqiharPeople’s Republic of China

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