Enzyme-responsive mechanism based on multi-walled carbon nanotubes and pectin complex tablets for oral colon-specific drug delivery system
The purpose of this work was to explore the potential application of MCNT as a colon-specific delivery system based on the enzyme responsive mechanism. A novel type of enzyme-sensitive colon-specific tablet (PM-tablet) based on pectin and multi-walled carbon nanotube (MCNT) was prepared by wet granulation tabletting method. The PM-tablet in the presence of pectinase exhibited enzyme degradation release and achieve a precise release in the colon. Our study had proposed a novel idea for the application of MCNT on the oral colon-specific drug delivery system.
KeywordsMulti-walled carbon nanotubes Colon Pectin Enyzme Tablet
This work was supported by the Qiqihar Medical University research fund project (No. QY2016B-01).
Compliance with ethical standards
Conflict of interest
The authors report no conflicts of interest.
- 1.De L (2015) Identification of hereditary nonpolyposis colorectal cancer in the general population. The 6-year experience of a population-based registry. Cancer 71:3493–3501Google Scholar
- 12.Hude RU (2017) Guar gum and HPMC coated colon targeted delivery of 6-mercapto-purine. J Nat Prod 7:18–29Google Scholar
- 19.Ohkami H (2010) Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis. Cancer Sci 86:523–529Google Scholar