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131I-labeled PEG and folic acid co-functionalized graphene quantum dots for tumor-targeted imaging

  • Yunhan Wang
  • Hu Song
  • Guanquan Wang
  • Xia Yang
  • Jing Wang
  • Hongyuan WeiEmail author
Article
  • 7 Downloads

Abstract

In this study, we successfully synthesized polyethylene glycol (PEG) and folic acid (FA) co-functionalized graphene quantum dots (GQDs) to improve the biocompatibility and tumor-targeting ability of GQDs simultaneously, and labeled GQDs–PEG–FA with 131I for biological behavior evaluation. The in vitro properties, biodistribution and SPECT imaging of 131I-GQDs–PEG–FA were investigated. The uptake of 131I-GQDs–PEG–FA at tumor sites can be clearly examined via SPECT imaging, which can ascribe to enhanced permeability and retention effect and active targeting effect of FA to folate receptors. The results indicate that 131I-GQDs–PEG–FA can be used as a radioactive probe for detection of tumor cells overexpressing folate receptor.

Keywords

Graphene quantum dots Polyethylene glycol Folic acid Active targeting Tumor 131

Notes

Acknowledgements

This work was financially supported by the National Nature Science Foundation of China (NSFC-21471138, NSFC-21401176).

Compliance with ethical standards

Conflict of interest

The authors of the manuscript declare that there is no conflict of interest.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2019

Authors and Affiliations

  1. 1.Department of Nuclear MedicineFirst Affiliated Hospital of Southwest Medical UniversityLuzhouPeople’s Republic of China
  2. 2.Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyangPeople’s Republic of China

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