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Stability evaluation of Tc-99m radiolabeled GRPr antagonist with amino acid chelators

  • Zhengkun Zhong
  • Wentao Kan
  • Wei Liao
Article
  • 11 Downloads

Abstract

In order to select a chelator with excellent stability, easier radiolabeling process and low cost, GRPr antagonist RM26 with the amino acid based chelator was radiolabeled with technetium-99m. The stability of the radiolabeled peptides in PBS, serum as well as in the presence of excess cysteine was compared.

Keywords

Technetium-99m Radiopeptide RM26 KGC N3S 

Notes

Acknowledgements

This research is financially supported by Science and Technology Development of Foundation of China Academy of Engineering Physics (2014A0301011) and China National Natural Science Foundation (21571164).

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018

Authors and Affiliations

  1. 1.Institute of Nuclear Physics and ChemistryChina Academy of Engineering PhysicsMianyangChina

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