68Ga-radiolabeled magnetic nanoparticles for PET–MRI imaging
In this study, magnetic multimodal nanoparticles with potential applications in magnetic- and nuclear-medicine imaging, magnetic resonance imaging, hyperthermia, and theranostic (therapeutic and diagnostic), applications were prepared by coating iron oxide nanoparticles with silica (core–shell), functionalizing with aminopropyltriethoxy silane and coupling with diethylenetriamine pentaacetic acid ligand (DTPA). Radiolabeling of core–shell–DTPA particles with 68Ga radiometal was carried out through chelation of 68Ga(III) ions by DTPA and was used for positron emission tomography. The biodistribution of the 68Ga-radiolabeled magnetic nanoparticles compared to free 68Ga(III) was checked in normal Balb/c mice up to 2 h.
KeywordsMagnetic nanoparticles Core–shell–DTPA Radiometal PET–MRI imaging 68Ga Bio-distribution
The financial support of Nuclear Science and Technology Research Institute (Grant Number Prog-C7-94-001) and Shahid Beheshti University is gratefully acknowledged.
- 4.Yan X, Jinhua Z (2014) Recent development of radiolabeled nanoparticles for PET imaging. Austin J Nanomed Nanotechnol 2:10–19Google Scholar
- 18.Kim K, Kim S, Chao Y (2007) Formation and surface modification of Fe3O4 nanoparticles by co-precipitation and sol–gel method. J Ind Eng Chem 13:1137–1141Google Scholar
- 23.Klooper F, Houser W, Atkins L (1971) Evaluation of 99mTc–DTPA for the measurement of glomerular filtration rate. J Nucl Med 13:107–114Google Scholar