Journal of Radioanalytical and Nuclear Chemistry

, Volume 317, Issue 2, pp 985–989 | Cite as

Production and isolation of 197m,gHg

  • John D. DespotopulosEmail author
  • Kelly N. Kmak
  • Dawn A. Shaughnessy


A new procedure has been developed for isolating no-carrier-added 197m,gHg from 20 to 25 MeV α-particle irradiations of high purity Pt foils. A previously published procedure for isolation of 197m,gHg from 12 to 15 MeV proton irradiations of Au foils has been further characterized. From these procedures two separate methods have been established to isolate, with high separation factors, 197m,gHg from Pt to Au target materials.


Mercury No-carrier-added Separation Extraction chromatography 



The authors would like to thank the CAMS facility staff at LLNL, specifically Scott Tumey, Thomas Brown and Graham Bench for providing beam time and expertise to the production of radionuclides used in this study. This study was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. This work was funded by the Laboratory Directed Research and Development Program at LLNL under project tracking code 17-LW-035.


  1. 1.
    Walther M, Lebeda O, Preusche S, Pietzsch H-J, Steinback J (2017) Theranostic mercury part 1: a new Hg/Au separation by a resin based method. AIP Conf Proc 1845:020023CrossRefGoogle Scholar
  2. 2.
    Walther M, Preusche S, Bartel S, Wunderlich G, Freudenberg R, Steinbach J, Pietzsch H-J (2015) Theranostic mercury: 197(m)Hg with high specific activity for imaging and therapy. Appl Radiat Isot 97:177–181CrossRefPubMedGoogle Scholar
  3. 3.
    Greif RL, Sullivan WJ, Jacobs GS, Pitts RF (1956) Distribution of radiomercury administered as labelled chlormerodrin (Neohydrin) in the kidneys of rats and dogs. J Clin Investig 35:38–43CrossRefPubMedGoogle Scholar
  4. 4.
    Mantricali B (1969) Brain scanning by means of 197Hg-labelled neohydrin. Psychiatr Neurol Neurochir 72:89–95Google Scholar
  5. 5.
    Chodil G, Jopson RC, Mark H, Swift CD, Thomas RG, Yates MK (1967) (p,n) and (p,2n) cross sections on nine elements between 7.0 and 15.0 MeV. Nucl Phys A 93:648–672CrossRefGoogle Scholar
  6. 6.
    Sudar S, Qaim SM (2006) Cross sections for the formation of 195Hgm,g, 197Hgm,g, and 196Aum,g in α and 3He-particle induced reactions on Pt: effect of level density parameters on the calculated isomeric cross-section ratio. Phys Rev C 73:034613CrossRefGoogle Scholar
  7. 7.
    Wilkniss PE, Beach LA, Marlow KW (1972) Production of carrier-free 197m,197Hg with a cyclotron. Radiochim Acta 17:110–113CrossRefGoogle Scholar
  8. 8.
    Hara T, Lio M, Hirata M, Karasawa T (1973) Cyclotron production of 197mHg and its use for lung tumor imaging. Int J Appl Radiat Isot 24:661CrossRefPubMedGoogle Scholar
  9. 9.
    Mandal S, Nayak D (2010) Production, separation and speciation of no-carrier-added Hg radionuclides using greener methodologies. Radiochim Acta 98:45–51CrossRefGoogle Scholar
  10. 10.
    Ghosh K, Lahiri S, Maiti M (2016) Separation of no-carrier-added 195m,gHg, 197mHg from Au target by ionic liquid and salt based aqueous biphasic systems. J Radioanal Nucl Chem 310:1381–1396CrossRefGoogle Scholar
  11. 11.
    Despotopulos JD, Kmak KN, Gharibyan N, Brown TA, Grant PM, Henderson RA, Moody KJ, Tumey SJ, Shaughnessy DA, Sudowe R (2015) Production and isolation of carrier-free homologs of flerovium and element 115 at the Lawrence Livermore National Laboratory Center for Accelerator Mass Spectrometry. J Radioanal Nucl Chem 308:567–572CrossRefGoogle Scholar
  12. 12.
    Rieman W, Walton HF (1970) Ion exchange in analytical chemistry: international series of monographs in analytical chemistry, vol 38. Pergamon Press, OxfordGoogle Scholar
  13. 13.
    National Nuclear Data Center “NNDC” (2013) Brookhaven National Laboratory. Accessed 4 Mar 2018
  14. 14.
    Kraus KA, Nelson F (1955) Distribution coefficients for adsorption of elements onto Dowex-A-1 anion exchange resin from hydrochloric acid. Proc of the First U.N. Conf Peac Uses Energy 7:113Google Scholar
  15. 15.
    Faris JP, Buchanan RF (1964) Anion exchange characteristics of elements in nitric acid medium. Anal Chem 36:1157–1158CrossRefGoogle Scholar
  16. 16.
    Marsh SF, Alarid JE, Hammond CF, McLeod MJ, Roensch FR, Rein JE (1978) Anion exchange of 58 elements in hydrobromic and in hydroiodic acid. Los Alamos National Laboratory Report LA-7084Google Scholar
  17. 17.
    Silver GL (1975) The dissolution and recovery of iridium in a nitrate system. J Less Common Met 40:265–267CrossRefGoogle Scholar
  18. 18.
    Despotopulos JD (2015) Studies of flerovium and element 115 homologs with macrocyclic extractants (Doctoral dissertation). ProQuest Ann Arbor 3715057:224Google Scholar

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2018

Authors and Affiliations

  • John D. Despotopulos
    • 1
    Email author
  • Kelly N. Kmak
    • 2
  • Dawn A. Shaughnessy
    • 1
  1. 1.Nuclear and Chemical Sciences DivisionLawrence Livermore National LaboratoryLivermoreUSA
  2. 2.University of California BerkeleyBerkeleyUSA

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