Journal of Radioanalytical and Nuclear Chemistry

, Volume 314, Issue 3, pp 1701–1706 | Cite as

Production of 89Sr-doped CdSe QDs@PAMAM as the radioanalytical-fluorescent indicator of renal injury and the preliminary application in diabetic nephropathy model

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Abstract

An indicator with double tracers has been developed so as to improve the accuracy and stability of quantitative analysis of renal injury. The indicator based on mono-dispersed 89Sr-doped CdSe QDs@PAMAM with tight core–shell structure and controllable size was synthesized. When intravenously injected in diabetic nephropathy models, the measurements of indicators in urine could effectively reflect the level of renal injury via both radioanalytical and florescent method, and comparable results were obtained with the creatinine in blood. The double trackable indicator of renal injury was capable to indirectly reflect the renal injury with improved accuracy and stability.

Keywords

Radioanalysis Fluorescence Renal injury Creatinine Diabetic nephropathy Quantum dots 
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Notes

Acknowledgements

This study was funded in part by the Programs of Science and Technology Bureau of Tangshan, Grant Number [10130265a, 05134601A-1].

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2017

Authors and Affiliations

  1. 1.Department of Community Health CareTangshan GongRen HospitalTangshanChina
  2. 2.Department of NephrologyTangshan GongRen HospitalTangshanChina
  3. 3.Department of HemodialysisTangshan GongRen HospitalTangshanChina

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