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PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study

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Abstract

The purpose of this study is to evaluate the biodistribution of polyethylene glycol (PEG) coated superparamagnetic iron oxide nanoparticles radiolabeled with 68Ga in normal mice after intravenous administration of this probe. Three mice were sacrificed at specific time intervals. The biodistribution data revealed high uptake by liver and spleen (60.62 and 12.65 %ID/g at 120 min post injection for liver and spleen, respectively). The clearance of other organs was fast. These results suggest that 68Ga-PEG-SPIONs has magnificent capabilities for applying in (PET-MRI) as a theranostic agent for detection of liver and spleen malignancies.

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Acknowledgments

We acknowledge the financial support of the International Atomic Energy Organization under ‘CRP F22064’.

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Authors and Affiliations

  1. Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Afsaneh Lahooti, Saeed Sarkar & Hamidreza Saligheh Rad

  2. Research Center for Molecular and Cellular Imaging, Tehran University of Medical Sciences, Tehran, Iran

    Saeed Sarkar

  3. Quantitative MR Imaging and Spectroscopy Group, Research Center for Cellular and Molecular Imaging, Tehran University of Medical Sciences, Tehran, Iran

    Hamidreza Saligheh Rad

  4. Department of Nuclear Medicine, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran

    Amir Gholami

  5. Department of Biology, Payame Noor University, Tehran, Iran

    Sahar Nosrati

  6. NMR and Molecular Imaging Laboratory, Department of General, Organic, and Biomedical Chemistry, University of Mons, Mons, Belgium

    Robert N. Muller, Sophie Laurent & Saeed Shanehsazzadeh

  7. Center for Microscopy and Molecular Imaging (CMMI), Rue Adrienne Bolland 8, 6041, Gosselies, Belgium

    Robert N. Muller & Sophie Laurent

  8. Micromod Partikeltechnologie GmbH, FriedrichBarnewitz-Str. 4, 18119, Rostock, Germany

    Cordula Grüttner

  9. Research Center for Nuclear Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Parham Geramifar

  10. Radiation Application Research School, Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran

    Hassan Yousefnia & Mohammad Mazidi

Authors
  1. Afsaneh Lahooti
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  2. Saeed Sarkar
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  3. Hamidreza Saligheh Rad
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  4. Amir Gholami
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  5. Sahar Nosrati
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  6. Robert N. Muller
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  7. Sophie Laurent
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  8. Cordula Grüttner
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  9. Parham Geramifar
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  10. Hassan Yousefnia
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  11. Mohammad Mazidi
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  12. Saeed Shanehsazzadeh
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Correspondence to Saeed Sarkar.

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Lahooti, A., Sarkar, S., Saligheh Rad, H. et al. PEGylated superparamagnetic iron oxide nanoparticles labeled with 68Ga as a PET/MRI contrast agent: a biodistribution study. J Radioanal Nucl Chem 311, 769–774 (2017). https://doi.org/10.1007/s10967-016-5058-0

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  • DOI: https://doi.org/10.1007/s10967-016-5058-0

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