15N-labelled pyrazines of triterpenic acids

  • Martin Vlk
  • Petra Micolova
  • Milan Urban
  • Miroslav Kvasnica
  • David Saman
  • Jan Sarek
Article

Abstract

Triterpenoid pyrazines from our research group were found selectively cytotoxic on several cancer cell lines with IC50 in low micromolar range. This sparked our interest in preparing their labeled analogs for metabolic studies. In this work, we prepared a set of non-labeled pyrazines from seven triterpenoid skeletal types along with their 15N labelled analogs. In this work, we present the synthesis and characterization of the target 15N labelled pyrazines. Currently, these compounds are being studied in complex metabolic studies.

Keywords

15Triterpenic acid Isotopic labelling Pyrazine Heterobetulinic acid 

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2015

Authors and Affiliations

  • Martin Vlk
    • 1
  • Petra Micolova
    • 1
  • Milan Urban
    • 2
    • 3
  • Miroslav Kvasnica
    • 4
  • David Saman
    • 5
  • Jan Sarek
    • 2
  1. 1.Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PraguePrague 1Czech Republic
  2. 2.Faculty of Medicine and Dentistry, Institute of Molecular and Translational MedicinePalacky University OlomoucOlomoucCzech Republic
  3. 3.Department of Organic Chemistry, Faculty of SciencePalacky University OlomoucOlomoucCzech Republic
  4. 4.Laboratory of Growth Regulators, Centre of the Region Hana for Biotechnological and Agricultural ResearchInstitute of Experimental Botany ASCR & Palacky UniversityOlomoucCzech Republic
  5. 5.Institute of Organic Chemistry and BiochemistryASCRPrague 6Czech Republic

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