Journal of Radioanalytical and Nuclear Chemistry

, Volume 303, Issue 1, pp 979–983 | Cite as

Astatine-211 labeling: a study towards automatic production of astatinated antibodies

  • Emma Aneheim
  • Holger Jensen
  • Per Albertsson
  • Sture Lindegren
Article

Abstract

Targeted alpha therapy is especially interesting for therapy of microscopic cancer tumors due to short path length and high linear energy transfer of the alpha particles. One of the most promising nuclides for targeted alpha therapy is 211At. To facilitate larger clinical studies using 211At, the current manual synthesis of radiolabeled antibodies would benefit from being transferred into an automated method. In this work, successful modifications of the manual synthesis have been performed in order to adapt it to automation. The automatic synthesis has also been tested using the modified synthesis method.

Keywords

211At Labeling Immunoconjugates Antibodies Radiopharmaceutical module 

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2014

Authors and Affiliations

  • Emma Aneheim
    • 1
  • Holger Jensen
    • 2
  • Per Albertsson
    • 1
  • Sture Lindegren
    • 1
  1. 1.Targeted Alpha Therapy Group, Department of Radiation PhysicsSahlgrenska Academy at Gothenburg UniversityGothenburgSweden
  2. 2.PET and Cyclotron UnitCopenhagen University HospitalCopenhagenDenmark

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