Advertisement

Preparation of 227Ac/223Ra by neutron irradiation of 226Ra

  • Ekaterina Kukleva
  • Ján KozempelEmail author
  • Martin Vlk
  • Petra Mičolová
  • Dušan Vopálka
Article

Abstract

Radium-223 is a prospective alpha-emitter for targeted radionuclide therapy. Although 223Ra is formed naturally by the decay of 235U, for practical reasons its preparation involves neutron irradiation of 226Ra. The β decay of the 227Ra (T ½ = 43 min) produced via 226Ra(n,γ)227Ra reaction leads to 227Ac, a mother nuclide of 227Th and subsequently 223Ra. Radium target material is generally available in multigram quantities from historical stock. The main aim of this study was to experimentally as well as theoretically evaluate and verify the available literature data on production of 227Ac/223Ra. According to the data obtained from the γ-spectra, the approximate yield values were determined and effective cross section value for the 227Ac production was calculated to 14 ± 4 b.

Keywords

Actinium 227Ac Radium 223Ra 226Ra Neutron irradiation 

Notes

Acknowledgments

This work was partially supported by the Ministry of Education Youth and Sports of the Czech Republic and the Technology Agency of the Czech Republic under grant agreements No.: LK21310 and TA03010027 respectively.

References

  1. 1.
    Larsen RH (2006) In vivo 20:325–332Google Scholar
  2. 2.
    Peterson S (1949) In: Seaborg GT, Katz JJ, Manning WU (eds) Transuranium elements, Part II, 1st edn. McGraw-Hill, New YorkGoogle Scholar
  3. 3.
    Weidner JW, Mashnik SG, John KD, Ballard B, Birnbaum ER (2012) Appl Radiat Isot 11:2590–2595CrossRefGoogle Scholar
  4. 4.
    Zhuikov BL, Kalmykov SN, Ermolaev SV, Aliev RA (2011) Radiochemistry 1:73–80CrossRefGoogle Scholar
  5. 5.
    Henriksen G (2001) Radiochim Acta 89:661–666CrossRefGoogle Scholar
  6. 6.
    Boll RA, Garland M and Mirzadeh S (2005) International conference on nuclear data for science and technology, American Institute of Physics Conference Proceedings 769:1674–1675Google Scholar
  7. 7.
    Kuznetsov RA, Butkalyuk PS, Baranov Yu, Butkalyuk IL, Romanov EG, Kupriyanov VN, Kazakova EV, Tarasov VA (2012) Radiochemistry 54:383–387CrossRefGoogle Scholar
  8. 8.
    Experimental nuclear reaction data—EXFOR database (2014) IAEA Vienna. https://www-nds.iaea.org/exfor/exfor.htm. Accessed 25 March 2014
  9. 9.
    Chu SYF, Ekström LP and Firestone RB (2009) The Lund/LBNL Nuclear Data Search, Version 2.0 http://nucleardata.nuclear.lu.se/database/nudat/. Accessed 25 March 2014
  10. 10.
    Evaluation of measurement data—Guide to the expression of uncertainty in measurement (2008) JCGM BIMP, Sèvres. http://www.bipm.org/utils/common/documents/jcgm/JCGM_100_2008_E.pdf. Accessed 25 May 2014

Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2014

Authors and Affiliations

  • Ekaterina Kukleva
    • 1
  • Ján Kozempel
    • 1
    Email author
  • Martin Vlk
    • 1
  • Petra Mičolová
    • 1
  • Dušan Vopálka
    • 1
  1. 1.Department of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical EngineeringCzech Technical University in PraguePrague 1Czech Republic

Personalised recommendations