Journal of Radioanalytical and Nuclear Chemistry

, Volume 291, Issue 2, pp 405–408 | Cite as

Radioiodine tracers as useful tools in studies of thyrotoxic effects of exogenous bromide and perchlorate ions

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Abstract

With the use of 125I and 131I radionuclides, we followed the effects of exogenous bromide and perchlorate ions on the metabolism of iodine and of thyroid hormone in the rat. The presumed thyrotoxic effects of bromide and perchlorate have been confirmed and quantified. Correct assay conditions for the radiometric determination of the enzyme activity of thyroid peroxidase (TPO) have been established. The use of the adapted radiometric assay revealed a divergent influence of bromide and perchlorate ions on the TPO activity in the rat thyroids. Excessive bromide exerted a biphasic effect, depending on the extent of bromide intake in the animals. In contrast, in all the rats that were administered with high amounts of perchlorate were found elevated TPO activities.

Keywords

Bromide Perchlorate Radioiodine tracer Thyroid hormone 

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2011

Authors and Affiliations

  1. 1.Central-European Technology InstituteMasaryk UniversityBrnoCzech Republic
  2. 2.Department of RadiometryInstitute of Physiology, Academy of Sciences of the Czech RepublicPrague 4Czech Republic

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