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Journal of Radioanalytical and Nuclear Chemistry

, Volume 286, Issue 1, pp 135–140 | Cite as

(S)-2-((S)-2-(4-(3-[18F]fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid labeled with 18F

  • Yong He
  • Rui Ding
  • Hang Liu
  • Xiao Wang
  • Jing-Li Xu
  • Man Feng
  • Yu-Rong Chen
  • Chuan-Min Qi
  • Cheng Peng
  • Zhao-Hui Zhu
  • Yong-Hong Dang
  • Ming Wang
  • Yun-Chuan Ma
Article

Abstract

As degradation product of Antineoplaston A10 in vivo, phenylacetyl glutamine showed antitumor activities. According to literatures, we designed and radiosynthesized a phenylacetyl glutamine derivative, which was achieved under a mild reaction condition. Evaluations in vitro and in vivo were performed on tumor bearing mice. Excitingly, the radiochemical purity of (S)-2-((S)-2-(4-(3-fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid ([18F]FBPPA) was 98%, and besides the best radiochemical yield was up to 46%. T/Bl (Tumor/Blood) and T/M (Tumor/Muscle) ratios of [18F]FBPPA at 60 min post injection were 2.33 and 3.51. Meanwhile, it showed satisfied stability in vitro and in vivo, compared with 2-[18F]fluorodeoxyglucose ([18F]FDG). Although [18F]FBPPA deserved further studies to make optimizations on its structure, the results revealed it might become a potential PET imaging agent for detecting tumors.

Keywords

18PET Tumor 

Abbreviation

[18F]FBPPA

(S)-2-((S)-2-(4-(3-fluoropropyl)benzamido)-3-phenylpropanamido)pentanedioic acid

Notes

Acknowledgments

We acknowledged with thanks for financial supports from the National Natural Science Foundation of China (No.20371009 and No.20671014), Key laboratory of Radioactive Medicine of Ministry Education and Beijing Municipal Commission of Education.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2010

Authors and Affiliations

  • Yong He
    • 1
  • Rui Ding
    • 1
  • Hang Liu
    • 1
  • Xiao Wang
    • 1
  • Jing-Li Xu
    • 1
  • Man Feng
    • 1
  • Yu-Rong Chen
    • 1
  • Chuan-Min Qi
    • 1
  • Cheng Peng
    • 2
  • Zhao-Hui Zhu
    • 3
  • Yong-Hong Dang
    • 3
  • Ming Wang
    • 1
  • Yun-Chuan Ma
    • 2
  1. 1.Key Laboratory of Radiopharmaceutical, College of ChemistryBeijing Normal UniversityBeijingChina
  2. 2.PET Center of Xuan Wu HospitalBeijingChina
  3. 3.Department of Nuclear Medicine, PUMC HospitalCAMS and PUMCBeijingChina

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