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Journal of Radioanalytical and Nuclear Chemistry

, Volume 281, Issue 2, pp 161–164 | Cite as

Changes of iron concentrations in skin and plasma of patients with hemochromatosis along therapy

  • T. Pinheiro
  • A. Barreiros
  • L. C. Alves
  • M. Neres
  • R. Fleming
  • J. N. Silva
  • P. Filipe
  • R. Silva
Article

Abstract

Skin as a manageable organ can provide direct or indirect information of tissue iron overload resulting from inherited disorders as hemochromatosis. Patients with hemochromatosis were evaluated at three consecutive phases along the therapy programme. Nuclear microprobe techniques were used to assess skin iron and Total Reflection X-ray Fluorescence to determine the plasma iron concentrations. Results showed that iron pools were differently correlated at the three therapy phases. These variations highlighted the value of skin iron content to assess organ iron deposition and therapy efficacy. Skin iron content can be used for a better management of patients with iron overload pathologies.

Keywords

Iron Human disorders Nuclear microprobe TXRF 

Notes

Acknowledgements

The work was carried out under SPDV (Portuguese Society of Dermatology and Venereology) and IAEA RC 302-F1.20.19-POR-13262 research contracts. The reference group for skin was established under the research contract EC/QLK4-CT-2002-02678.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  • T. Pinheiro
    • 1
    • 2
  • A. Barreiros
    • 3
  • L. C. Alves
    • 1
  • M. Neres
    • 1
  • R. Fleming
    • 4
  • J. N. Silva
    • 5
  • P. Filipe
    • 5
  • R. Silva
    • 5
  1. 1.Instituto Tecnológico e NuclearSacavémPortugal
  2. 2.Centro de Física NuclearUniversidade de LisboaLisbonPortugal
  3. 3.Instituto Nacional de EngenhariaTecnologia e InovaçãoLisbonPortugal
  4. 4.Serviço de Imuno-HemoterapiaHospital de Santa MariaLisbonPortugal
  5. 5.Clínica Universitária de Dermatologia, Hospital de Santa MariaLisbonPortugal

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