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Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer

  • S. Watanabe
  • Y. Iida
  • N. Suzui
  • T. Katabuchi
  • S. Ishii
  • N. Kawachi
  • H. Hanaoka
  • S. Watanabe
  • S. Matsuhashi
  • K. Endo
  • N. S. Ishioka
Article

Abstract

Copper-64 was produced by the 64Ni(p, n)64Cu reaction using enriched 64NiO target. We investigated and compared the production yield of 64Cu for proton beams of various energies by using a thick target. Enriched 64Ni was recovered with high yield by simple procedures. Imaging studies using positron emission tomography (PET) and positron emitting tracer imaging system (PETIS) were performed. We obtained clear images in PET and PETIS studies. The results of this study indicate that 64Cu can be utilized as a biomedical tracer for the molecular imaging both in animals and plants.

Keywords

Positron Emission Tomography Positron Emission Tomography Imaging Proton Beam Thick Target Wide Energy Range 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Akadémiai Kiadó, Budapest, Hungary 2009

Authors and Affiliations

  • S. Watanabe
    • 1
  • Y. Iida
    • 2
    • 3
  • N. Suzui
    • 1
  • T. Katabuchi
    • 5
  • S. Ishii
    • 1
  • N. Kawachi
    • 1
  • H. Hanaoka
    • 2
  • S. Watanabe
    • 1
  • S. Matsuhashi
    • 1
  • K. Endo
    • 3
    • 4
  • N. S. Ishioka
    • 1
  1. 1.Plant Positron Imaging Group, Quantum Beam Science DirectorateJapan Atomic Energy AgencyGunmaJapan
  2. 2.Department of Bioimaging Information AnalysisOsakaJapan
  3. 3.21st century COE ProgramOsakaJapan
  4. 4.Department of Diagnostic Radiology and Nuclear MedicineGunma University Graduate School of MedicineGunmaJapan
  5. 5.Research Laboratory for Nuclear ReactorsTokyo Institute of TechnologyMeguro, TokyoJapan

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