Journal of Radioanalytical and Nuclear Chemistry

, Volume 279, Issue 1, pp 209–218 | Cite as

In vitro dissolution study of uranium dioxide and uranium ore with different particle sizes in simulated lung fluid

  • Weijia Li
  • R. Skinner
  • K. Megna
  • Jing Chen
  • S. Perera
  • J. Murimboh
  • E. Waller
  • L. Erhardt
  • R. J. Cornett
Article
  • 85 Downloads

Abstract

Inhalation is one of the most important routes for aerosol particles of uranium compounds to enter the body. The main step for uranium to be available for blood circulation and for interaction with bio-molecules is the dissolution of the particles. Particle size effects on dissolution of uranium dioxide and uranium ore were studied in simulated lung fluid using the “batch/filter” method. Samples were fractionated to ten size ranges from <0.43 μm to >10 μm by cascade impaction prior to dissolution experiments. Dependence of dissolution kinetics on particle size and on the amount of uranium trioxide contained in the particles was observed.

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References

  1. 1.
    K. H. Lieser, Nuclear and Radiochemistry, Fundamentals and Applications, Wiley-VCH, Berlin, 2001.Google Scholar
  2. 2.
    J. N. Stannard, Ann. Rev. Pharmacol., 13 (1973) 325.CrossRefGoogle Scholar
  3. 3.
    M. D. Sztajnkrycer, E. J. Otten, Mil. Med., 169 (2004) 212.Google Scholar
  4. 4.
    ICRP, International Commission on Radiation Protection (ICRP), Human Respiratory Tract Model for Radiological Protection, ICRP Publication 66, Pergamon Press, Oxford, U.K., 1994.Google Scholar
  5. 5.
    ICRP, International Commission on Radiological Protection (ICRP), Limits for Intakes of Radionuclides by Workers, ICRP Publication 30, Pergamon Press, New York, 1979.Google Scholar
  6. 6.
    J. Heyder, Proc. Am. Thorac. Soc., 1 (2004) 315.CrossRefGoogle Scholar
  7. 7.
    J. Heyder, J. Gebhart, G. Rudolf, C. F. Schiller, W. Stahlhofen, J. Aerosol Sci., 17 (1986) 811.CrossRefGoogle Scholar
  8. 8.
    M. B. Dolovich, M. Jordana, M. T. Newhouse, Eur. J. Nucl. Med., 13 Suppl (1987) S45.Google Scholar
  9. 9.
    M. Sutton, S. R. Burastero, Chem. Res. Toxicol., 17 (2004) 1468.CrossRefGoogle Scholar
  10. 10.
    A. F. Eidson, W. C. Griffith Jr., Health Phys., 46 (1984) 151.Google Scholar
  11. 11.
    T. E. Heffernan, J. C. Lodwick, H. Spitz, J. Neton, M. Soldano, Health Phys., 80 (2001) 255.Google Scholar
  12. 12.
    D. R. Kalkwarf, Sci. Total Environ., 28 (1983) 405.CrossRefGoogle Scholar
  13. 13.
    G. J. Newton, G. M. Kanapilly, Annual Report of the Inhalation Toxicology Research Institute (Lovelace Biomedical and Environmental Research Institute), 1976, p. 15.Google Scholar
  14. 14.
    N. A. Dennis, H. M. Blauer, J. E. Kent, Health Phys., 42 (1982) 469.Google Scholar
  15. 15.
    O. R. Moss, Health Phys., 36 (1979) 447.Google Scholar
  16. 16.
    S. Sdraulig, R. Franich, R. Tinker, S. Solomon, R. O’Brien, P. Johnston, J. Environ. Radioact., (2007) to be published.Google Scholar
  17. 17.
    E. Ansoborlo, J. Chalabreysse, M. H. Henge-Napoli, E. Pujol, Environ. Health Perspect., 97 (1992) 139.CrossRefGoogle Scholar
  18. 18.
    P. E. Morrow, F. R. Gibb, H. D. Beiter, Health Phys., 23 (1972) 273.CrossRefGoogle Scholar
  19. 19.
    N. M. Davies, M. R. Feddah, Intern. J. Pharmaceut., 255 (2003) 175.CrossRefGoogle Scholar
  20. 20.
    E. A. Maynard, H. C. Hodge, The Pharmacology and Toxicology of Uranium Compounds, McGraw Hill, New York, 1949.Google Scholar

Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Weijia Li
    • 1
  • R. Skinner
    • 1
  • K. Megna
    • 2
  • Jing Chen
    • 1
  • S. Perera
    • 2
  • J. Murimboh
    • 3
  • E. Waller
    • 2
  • L. Erhardt
    • 4
  • R. J. Cornett
    • 1
  1. 1.Radiation Protection Bureau, Health Canada, A.L.:6302D1OttawaCanada
  2. 2.School of Energy Engineering and Nuclear ScienceUniversity of Ontario Institute TechnologyNorth OshawaCanada
  3. 3.Department of ChemistryAcadia UniversityWolfvilleCanada
  4. 4.Defence R&D Canada — OttawaOttawaCanada

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