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Synthesis, quality control and biodistribution of 99mTc-Kanamycin

  • S. Roohi
  • A. Mushtaq
  • M. Jehangir
  • S. A. Malik
Article

Summary

Kanamycin is an antibiotic used for treatment of infections when penicillin or other less toxic drugs cannot be used. Kanamycin was labeled with technetium-99m pertechnetate using SnCl2 . 2H2O as reducing agent. The labeling efficiency depends on the ligand/reductant ratio, pH, and volume of reaction mixture. Radiochemical purity and stability of 99mTc-Kanamycin was determined by thin layer chromatography. Biodistribution studies of 99mTc-Kanamycin were performed in rats and rabbits. A significantly higher accumulation of 99mTc-Kanamycin was seen at sites of S. aureusinfected animals (rat/rabbit).

Keywords

Chromatography Physical Chemistry 2H2O Inorganic Chemistry Quality Control 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag/Akadémiai Kiadó 2006

Authors and Affiliations

  • S. Roohi
    • 1
  • A. Mushtaq
    • 2
  • M. Jehangir
    • 3
  • S. A. Malik
    • 4
  1. 1.Isotope Production Division, Pakistan Institute of Nuclear Science and Technology
  2. 2.Isotope Production Division, Pakistan Institute of Nuclear Science and Technology
  3. 3.Isotope Production Division, Pakistan Institute of Nuclear Science and Technology
  4. 4.Department of Biological Sciences, Quaid-e-Azam University

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