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Journal of Polymer Research

, 26:290 | Cite as

A new coordination polymer for selectively detect TNP and its inhibition activity on P.gingivalis growth by reducing ragA and ragB gene expression

  • Xu Wang
  • Dai-Qing LiEmail author
  • Jun Zhao
  • Chao Wei
ORIGINAL PAPER
First Online:

Abstract

A four-fold interpenetrated Zn(II)-based coordination polymer with the chemical formula of {[Zn2(L)2(bdc)]·(H2O)2·DMF}n (1) was synthesized by solvent method using terephthalic acid (H2bdc) and N1,N1,N4,N4-tetrakis(4-(1H-imidazol-1-yl)phenyl)benzene-1,4-diamine (L) as the mixed ligands. The as-prepared complex 1 was measured via the elemental analysis and single crystal X-ray diffraction. Furthermore, due to its strong intense emission, complex 1 could be applied as luminescent sensor to sensitively detect 2,4,6-trinitrophenol (TNP), which has the characteristics of high sensitivity and selectivity. In addition, to evaluate the anti-bacterial effect of compound 1 in vitro, the P.gingivalis growth curves were measured. And the relative expression of ragA and ragB was detected by RT-PCR to reveal the mechanism of the compound in the anti-infectious activity. The potential anti-infectious criteria that has been observed in the experimental measurement has been further studied by using molecular docking technique.

Keywords

Coordination polymer Mixed-ligand Luminescent sensor Anti-infectious activity Molecular docking 
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Notes

Acknowledgements

The research did not receive any specific funding.

Compliance with ethical standards

Conflict of interest

The author(s) declare(s) that there is no conflict of interest regarding the publication of this paper.

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Copyright information

© The Polymer Society, Taipei 2019

Authors and Affiliations

  1. 1.Department of Infectious DiseasesThe First Hospital of JiaxingJiaxingChina
  2. 2.Department of StomatologyChina Armed Force Coast Guard General HospitalJiaxingChina
  3. 3.Second Department of Internal MedicineZhuji Central Hospital of Zhejiang ProvinceZhujiChina
  4. 4.Department of NeurosurgeryZhuji People’s Hospital of Zhejiang ProvinceZhujiChina

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