Adhesive, self-healing and antibacterial properties of Cu-coordinated soft gel based on histamine-conjugated polyaspartamide
Metal-ligand coordination bonding is a non-covalent interaction that has been extensively studied as an effective way to improve the mechanical properties of hydrogels or to generate novel supramolecular self-healing gels. In this study, biodegradable polyaspartamide derivatives conjugated with histamine were synthesized and used to prepare the metal-coordinated supramolecular gel with several different metal-ions such as Cu(II), Ni(II), and Zn(II) in an aqueous solution. The resulting gels showed high adhesive properties on glass and plastics substrates, and the adhesive strength could be modulated by using different metal-ion species as well as the concentration and medium pH. In particular, the Cu(II)-coordinated gel exhibited a reversible self-healing behavior and good antibacterial activity. These wholly bio-based supramolecular polymer gels have potential for various biomedical applications with their multifunctional properties comprising adhesive, self-healing and antimicrobial properties in wet gel state.
KeywordsMetal-coordination Supramolecular hydrogel Adhesive Self-healing Antibacterial Poly(amino acid)
This work was supported by the Basic Science Research Program through the National Research Foundation (NRF) of Korea, funded by the Ministry of Education, Science and Technology (NRF-2016R1D1A1A09918727).
- 4.Seo JH, Lee JS, Kim JH (2015) Swelling characteristics and Pb(II) ion adsorption properties of superabsorbent gel based on dopamine-conjugated poly(aspartic acid). Polym-Korea 39:917–924Google Scholar
- 7.Bode S, Bose RK, Matthes S, Ehrhardt M, Seifert A, Schacher FH, Paulus RM, Stumpf S, Sandmann B, Vitz A, Winter A, Hoeppener S, Garcia SJ, Spange S, van der Zwaag S, Hager MD, Schubert US (2013) Self-healing metallopolymers based on cadmium bis(terpyridine) complex containing polymer networks. Polym Chem 4:4966–4973CrossRefGoogle Scholar
- 18.Moon JR, Kim JH (2010) Biodegradable stimuli-responsive hydrogels based on amphiphilic polyaspartamides with tertiary amine pendent groups. Polym Int 59:630–636Google Scholar
- 28.Yi X, He J, Wang X, Zhang Y, Tan G, Zhou Z, Chen J, Chen D, Wang R, Tian W, Yu P, Zhou L, Ning C (2018) Tunable mechanical, antibacterial, and cytocompatible hydrogels based on a functionalized dual network of metal coordination bonds and covalent crosslinking. ACS Appl Mater Interface 10:6190–6198CrossRefGoogle Scholar
- 30.Trojer MA, Movahedi A, Blanck H, Nyden M (2013) Imidazole and triazole coordination chemistry for antifouling coating. J Chem 2018: ID 946739:23Google Scholar
- 32.Klingkajon W, Supaphol P (2014) Novel copper (II) alginate hydrogels and their potential for use as anti-bacterial wound dressings. Biomed Mater 99: 045008:11Google Scholar
- 37.Vlasak J, Rypacek F, Drobnik J, Saudek V (1979) Properties and reactivity of polysuccinimide. J Polym Sci 66:59–64Google Scholar
- 38.Tran NB, Kim JY, Kim YC, Kim YJ, Kim JH (2015) CO2-responsive swelling behavior and metal-ion adsorption properties in novel histamine-conjugated polyaspartamide hydrogel. J Appl Polym Sci 133:43305Google Scholar
- 39.Tella AC, Obaleye JA (2010) Metal complexes as antibacterial agents: Synthesis, characterization and antibacterial activity of some 3d metal complexes of sulphadimidine. Orbital Elec J Chem 2:11–26Google Scholar