Advertisement

Preparation and characterization of sustained release system based on polyanhydride microspheres with core/shell-like structures

  • I-Ming Chu
  • Tsang-Hao Liu
  • Yu-Ru Chen
ORIGINAL PAPER
  • 4 Downloads

Abstract

A system for localized drug delivery composed of polyanhydride polymers was studied. The polymers were made via melt-condensation of sebacic acid (SA) with different amount of 1, 3-bis (p-carboxyphenoxy) propane (CPP) as copolymers. By double emulsion technique, microspheres with core/shell-like structure were fabricated. Hydrophilic compound Brilliant Blue G (BBG) was encapsulated in the inner core(s) region with loading efficiencies of 50% ~ 60% for poly (SA) and 40% ~ 45% for poly(SA-CPP) copolymer. Hydrophobic compound, curcumin, was encapsulated in the outer shell region at efficiencies about 90%. Drug release profiles show no initial burst and stable release rates. The studied delivery system was showed to provide stable release for both hydrophilic and hydrophobic compounds simultaneously.

Keywords

Polyanhydride Microspheres Sustained release Curcumin 

Notes

Acknowledgments

This research is supported by grant 104-2221-E-007-126-MY3 from Ministry of Science and Technology, Taiwan.

Compliance with ethical standards

Conflict of interests

The authors claim no conflict of interests in this study.

Supplementary material

10965_2018_1657_MOESM1_ESM.pdf (156 kb)
ESM 1 (PDF 155 kb)

References

  1. 1.
    Chason M, Langer R (1990) Biodegradable polymers as drug release systems. Marcel Dekker, New YorkGoogle Scholar
  2. 2.
    Hsu SP, Chu IM (2012). J Polym Res 19:9913–9916CrossRefGoogle Scholar
  3. 3.
    Pavelkova A, Kucharczyk P, Zednik J, Sedlarik V (2014) Synthesis of poly(sebacic anhydride): effect of various catalysts on structure and thermal properties. J Polym Res 21:426CrossRefGoogle Scholar
  4. 4.
    Kumar N, Langer R, Domb A (2002) Polyanhydrides: an overview. Adv Drug Deliv Rev 54:889–910CrossRefGoogle Scholar
  5. 5.
    Conix A (1958) Aromatic polyanhydrides, a new class of high melting fiber-forming polymers. J Polym Sci 29:343–353CrossRefGoogle Scholar
  6. 6.
    Nagata M, Ioka E (2006) Synthesis and degradation of novel photocrosslinkable aromatic copolyanhydrides. Eur Polym J 42:2617–2622CrossRefGoogle Scholar
  7. 7.
    Domb AJ (1992) Synthesis and characterization of biodegradable aromatic anhydride copolymers. Macromolecules 25:12–17CrossRefGoogle Scholar
  8. 8.
    Göpferich A, Tessmar J (2002) Polyanhydride degradation and erosion. Adv Drug Deliv Rev 54:911–931CrossRefGoogle Scholar
  9. 9.
    Chan CK, Chu IM (2005) In vitro release of incorporated model compounds in poly(sebacic anhydride-co-ethylene glycol). Eur Polym J 41:1403–1409CrossRefGoogle Scholar
  10. 10.
    Lee WC, Chu IM, Biomed J (2008). Mater Res B, Appl Biomater 84:138–146CrossRefGoogle Scholar
  11. 11.
    Hong DW, Liu TH, Chu IM (2010). J Biotechnol 150:S445CrossRefGoogle Scholar
  12. 12.
    Tabata Y, Langer R (1993) Polyanhydride microspheres that display near-constant release of water-soluble model drug compounds. Pharm Res 10:391–399CrossRefGoogle Scholar
  13. 13.
    Pekarek KJ, Dyrud MJ (1996) In vitro and in vivo degradation of double-walled polymer microspheres. J Control Release 40:169–178CrossRefGoogle Scholar
  14. 14.
    Leach KJ, Mathiowitz E (1998) Degradation of double-walled polymer microspheres of PLLA and P(CPP:SA)20:80. I. In vitro degradation. Biomaterials 19:1973–1980CrossRefGoogle Scholar
  15. 15.
    Sun L, Zhou S (2009). J Mater Sci Mater Med 20:2035–2042CrossRefGoogle Scholar
  16. 16.
    Bajaj I, Singhal R (2011) Poly (glutamic acid) – An emerging biopolymer of commercial interest. Bioresour Technol 102:5551–5561CrossRefGoogle Scholar
  17. 17.
    Li C (2002) Poly(l-glutamic acid)–anticancer drug conjugates. Adv Drug Deliv Rev 54:695–713CrossRefGoogle Scholar
  18. 18.
    Berkland C, King M, Cox A, Kim K, Pack DW (2002) Precise control of PLG microsphere size provides enhanced control of drug release rate. J Control Release 82:137–147CrossRefGoogle Scholar
  19. 19.
    Hong DW, Liu TH, Chu IM (2011) Encapsulation of curcumin by methoxy poly(ethylene glycol-b-aromatic anhydride) micelles. J Appl Polym Sci 122:898–907CrossRefGoogle Scholar
  20. 20.
    Kipper MJ, Shen E, Determan A, Narasimhan B (2002) Design of an injectable system based on bioerodible polyanhydride microspheres for sustained drug delivery. Biomaterials 23:4405–4412CrossRefGoogle Scholar
  21. 21.
    Bibby DC, Davies NM, Tucker IG (1999) Poly(acrylic acid) microspheres containing β-cyclodextrin: loading and in vitro release of two dyes. Int J Pharm 187:243–250CrossRefGoogle Scholar
  22. 22.
    Sun L, Zhou S, Wang W, Su Q, Li X (2009) Preparation and characterization of protein-loaded polyanhydride microspheres. J Mater Sci-Mater Med 20:2035–2042CrossRefGoogle Scholar

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Chemical EngineeringNational Tsing Hua UniversityHsinchuTaiwan

Personalised recommendations