Synthesis of pH-responsive cellulose-g-P4VP by atom transfer radical polymerization in ionic liquid, loading, and controlled release of aspirin
- 76 Downloads
A pH-responsive cellulose-g-P4VP copolymer was synthesized by atom transfer radical polymerization (ATRP) in ionic liquid 1-allyl-3-methylimidazolium chloride [AMIM]Cl. The polymer structure was characterized by Fourier transform infrared (FT-IR), 1H nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). The P4VP brushes that were covalently bonded to the cellulose backbone had a narrow molecular weight distribution, which was helpful for use in drug loading. The loading and controlled release of drug using aspirin as model drug in the micelles obtained the cellulose-g-P4VP copolymer was investigated. The structure and size of the copolymeric micelles were characterized by transmission electron microscopy (TEM), dynamic light scattering (DLS) and ultraviolet–visible (UV-Vis) spectroscopy, respectively. Blank micelles presented a stably spherical morphology with dimeter about 90 nm in aqueous solution. The resultant micelles had clear pH-sensitivity with a pH-dependent phase transition point at a pH of about 5.7. Drug-loaded micelles had a spherical, core–shell structure with dimeter about 150 nm. The polymeric micelles revealed an excellent controlled drug release at different pH values and the cumulative release of aspirin in phosphate buffer reached to 86.4% at pH 5.8, 60.9% at pH 7.4 and 42.2% at pH 8.0.at 50 h. The pH-sensitive cellulose-g-P4VP copolymer had an enormous potential as carriers for released drug delivery.
KeywordsATRP Cellulose graft polymers pH-sensitivity Drug loading Controlled release Aspirin
The authors are grateful to the financial support by National Natural Science Foundation of China (No.21304030), Key basic research project in Hebei province, China (No.18961211D), Natural Science Foundation of Hebei Province, China (No.B2013208183) and Scientific Research Foundation for returned scholars preferred project of Hebei Province, China (No. C201400516).
- 9.Zhang SJ, Lv XM (2006) The ionic liquids-from basic research to industrialapplication1th edn. Science Press, Beijing (Chapter 6)Google Scholar
- 15.Yan Q, Yuan JY, Zhang FB, Sui XF, Xie XM, Yin YW, Wang SF, Wei Y (2009) Cellulose-based dual graft molecular brushes as potential drug nanocarriers: stimulus-responsive micelles, self-assembled phase transition behavior, and tunable crystalline morphologies. Biomacromolecules 10:2033–2042CrossRefPubMedGoogle Scholar
- 19.Ratnasinghc LD, Graubard BL, Kaele L, Tangrea JA, Taylor PR, Hawk E (2004) Aspirin use and mortality from cancer in a prospective cohort study. Anticancer Res 24:3177–3184Google Scholar