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Physicochemical and disintegrant properties of sodium Carboxymethyl starch derived from Borassus aethiopum (Arecaceae) shoot

  • Shadrack Joel Madu
  • Chukwuemeka Paul Azubuike
  • Omotunde Okubanjo
  • Achor Mohammed
  • Ochubiojo Martins Emeje
ORIGINAL PAPER
  • 40 Downloads

Abstract

Sodium carboxymethyl starch (CMS) samples synthesized from an under-utilized shoot of Borassus aethiopum were characterized and compared with a commercial brand, sodium starch glycolate. Effects of carboxylation on the physicochemical properties of the samples were examined by FTIR, XRD and SEM techniques. The rheological, micromeritics and disintegrant properties of the samples were also examined. The CMS samples had variable degree of substitution (DS) with the lowest DS (0.11) comparable to sodium starch glycolate in terms of desirable micromeritics, rheological and disintegrant properties. FTIR and XRD established modification of the native starch by showing an intense band around 1588 cm−1 to 1608 cm−1 and reduction in the peak intensities for the CMS samples respectively. CMS with variable DS and desirable micromeritics and rheological properties for potential applications as excipients in biopolymer industries could be obtained from Borassus aethiopum shoots.

Keywords

Borassus aethiopum Sodium carboxymethyl starch Physicochemical properties Micromeritics properties Disintegrant 

Notes

Compliance with ethical standards

Conflict of interest

None.

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Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  1. 1.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of PharmacyUniversity of LagosLagosNigeria
  2. 2.Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of PharmacyUniversity of MaiduguriMaiduguriNigeria
  3. 3.Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical SciencesUsmanu Danfodiyo University SokotoSokotoNigeria
  4. 4.Centre for Nanomedicine and Biophysical Drug DeliveryNational Institute for Pharmaceutical Research and DevelopmentAbujaNigeria

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