Octreotide end-functionalized diblock copolymers facilitated by RAFT polymerization

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Abstract

The incorporation of biologically active targeting ligands into polymeric materials is a key challenge in drug delivery and bioimaging. Reported here is the synthesis of diblock copolymers end-functionalized with the Somatostatin analog Octreotide. This methodology employs a novel Octreotide functional reversible addition-fragmentation chain transfer (RAFT) polymerization chain transfer agent, which is used to mediate the polymerization of N-isopropylacrylamide and subsequent chain-extension with N,N-dimethylacrylamide.

Keywords

Polymer-peptide conjugate RAFT polymerization Grafting-from End-functionalized 
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Notes

Acknowledgments

This research was supported by the JCO Grant (1131CFG002) of A* Star (Agency for Science Technology and Research).

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Copyright information

© Springer Science+Business Media Dordrecht 2017

Authors and Affiliations

  1. 1.Institute of Chemical and Engineering Sciences (ICES), A* Star SingaporeJurong IslandSingapore

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