Developmental Change in Adolescent Delinquency: Modeling Time-Varying Effects of a Preventative Intervention and GABRA2 Halpotype Linked to Alcohol Use
Better integrating human developmental factors in genomic research is part of a set of next steps for testing gene-by-environment interaction hypotheses. This study adds to this work by extending prior research using time-varying effect modeling (TVEM) to evaluate the longitudinal associations between the PROSPER preventive intervention delivery system, a GABRA2 haplotype linked to alcohol use, and their interaction on adolescent delinquency. Logistic and Poisson analyses on eight waves of data spanning ages 11 to 19 (60% female, 90% Caucasian) showed the intervention reduced delinquency from ages 13 to 16. Moreover, interaction analysis revealed that the effect of the multicomponent intervention was significantly greater for T-allele carriers of the GABRA2 SNP rs279845, but only during the 13 to 16 age period. The results are discussed in terms of adolescent delinquency normativeness, implications for preventive intervention research, and the utility of incorporating development in GxE research.
KeywordsDelinquency GABRA2 Intervention GxE Genetic
The authors would like to thank Dr. Deborah Grove and Ms. Ashley Price of the Penn State Genomics Core Facility for DNA purification and genotyping. For participant recruitment we recognize the efforts of Shirley Huck, Cathy Owen, Debra Bahr, and Anthony Connor of the Iowa State University Survey and Behavioral Research Services; Rob Schofield and Dean Stankowski of the Penn State University Survey Research Center; and Lee Carpenter, Kerry Hair, and Amanda Griffin of Penn State.
GS conceived the analyses reported in this article, drafted the manuscript, and analyzed and interpreted the data; AD helped analyze and interpret the data; HC, DV, MF, MG, RS, and CR conceived of the study, participated in its design and coordination, and helped draft the manuscript. All authors read and approved the final manuscript.
Work on this article was supported by the National Institute of Drug Abuse (grants DA030389 and DA013709). All authors read and approved the final manuscript.
Data Sharing and Declaration
This manuscript’s data is not publicly available.
Compliance with Ethical Standards
Conflict of Interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards
Informed consent was obtained from all individual participants included in the study.
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