Journal of Solution Chemistry

, Volume 42, Issue 2, pp 441–458 | Cite as

Kinetic Studies on Interaction of Platinum(II) Complexes with an ‘S’ Containing Ligand in Aqueous Medium

  • Parnajyoti Karmakar
  • Sumon Ray
  • Debabrata Nandi
  • Arup Mandal
  • Subala Mondal
  • Subhasis Mallick
  • Biplab K. Bera
  • Alak K. GhoshEmail author


The kinetics of the substitution reactions of [Pt(dach)(H2O)2]2+ and [Pt(en)(H2O)2]2+ (where ‘dach’ and ‘en’ are cis-1,2-diaminocyclohexane and ethylenediamine, respectively) with excess N,N′-diethylthiourea have been studied in aqueous solution by UV–Vis spectrophotometry. The effect of different N–N spectator ligands on the reactivity of platinum(II) complexes was investigated by studying the water lability of the reactant complexes. The kinetic study has been substantiated by product isolation, IR, NMR and ESI-MS spectral analysis and DFT calculations. The reactions follow normal square-planar substitution mainly in an associative way. Rate parameters have been evaluated under different conditions. The substitution rates of the complexes studied can be tuned through the nature of the N–N chelates, which is important in the development of new active compounds for cancer therapy.


Pt(II) Interaction N,N′-diethylthiourea Aqueous medium 


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Parnajyoti Karmakar
    • 1
  • Sumon Ray
    • 1
  • Debabrata Nandi
    • 1
  • Arup Mandal
    • 1
  • Subala Mondal
    • 1
  • Subhasis Mallick
    • 1
  • Biplab K. Bera
    • 1
  • Alak K. Ghosh
    • 1
    Email author
  1. 1.Department of ChemistryThe University of BurdwanBurdwanIndia

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