Rational synthesis of magnetic Fe3O4@MOF nanoparticles for sustained drug delivery
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Drug delivery carrier for targeted and controlled drug release is very important but challenging. In this work, a nano-sized metal–organic frameworks (MOFs)-based magnetic core–shell nanoparticles (NPs) has been designed for targeted drug delivery. Fe3O4@MIL-100(Fe) magnetic NPs were successfully prepared by a facile step-by-step assembly method. By the combination of the high porosity of MOFs shell and the magnetic characteristics of Fe3O4 core, making Fe3O4@MIL-100(Fe) magnetic NPs as an excellent drug delivery system. Significantly, the anti-inflammatory drug Ibuprofen (IBU) was effectively loaded on the magnetic NPs with a loading capacity of 0.31 g g−1, and it took as long as 70 h to release IBU completely in PBS buffer solution at 37 °C. This work demonstrates that the nano-sized MOFs-based magnetic NPs are promising candidates for targeted drug delivery applications.
KeywordsMetal–organic frameworks Porous materials Magnetic nanoparticles Core–shell Drug delivery
This work was supported by the National Natural Science Foundation of China (NSFC, 21501003), Natural Science Foundation of Anhui Province (1608085QB27), and China Postdoctoral Science Foundation funded project (2015M581973).