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Journal of Porous Materials

, Volume 24, Issue 2, pp 389–401 | Cite as

Synthesis, characterization, and drug release properties of macroporous dual stimuli responsive stereo regular nanocomposites gels of poly(N-isopropylacrylamide) and graphene oxide

  • Elvan Sulu
  • Chandra Sekhar Biswas
  • Florian J. Stadler
  • Baki Hazer
Article

Abstract

Nanocomposite stereoregular hybrid gels of poly(N-isopropylacrylamide) were prepared in 1:1 methanol–water mixture in the presence rare earth yttrium trifluoromethanesulfonate Lewis acid and graphene oxide (GO). The nanocomposite gels were characterized by swelling ratio measurements at different temperatures and different pH, deswelling kinetics, scanning electrone microscopy, FTIR, thermogravimetric analysis, powder XRD, Raman spectroscopy, LCST measurement by DSC etc. Drug release experiments also done by using tramadol hydrochloride as a model drug to check their suitability in application. All results were explained on the basis of porosity, cononsolvency of the synthesis solvents, hydrophilicity, isotacticity, pH effect, interactions between solvents and polymer molecules, interactions between polymer and GO or interactions between GO and solvents etc.

Keywords

Poly(N-isopropylacrylamide) macroporous gel Graphene oxide Nanocomposites Lewis acid 

Notes

Acknowledgments

We gratefully acknowledge the financial support from TUBITAK, Government of Turkey, through 2216 fellowship program for the foreign citizens and Bülent Ecevit University (#2013-7211-8496-02). The authors also thank the National Science Foundation of China (21574086), Nanshan District Key Lab for Biopolymers and Safety Evaluation (No. KC2014ZDZJ0001A), Shenzhen Sci and Tech research Grant (ZDSYS201507141105130), and Shenzhen City Science and Technology Plan Project (JCYJ20140509172719311) for financial support. We thank Prof. Kevin Cavicchi, University of Akron for comments on this manuscript.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Elvan Sulu
    • 1
  • Chandra Sekhar Biswas
    • 1
    • 2
  • Florian J. Stadler
    • 2
  • Baki Hazer
    • 1
  1. 1.Department of ChemistryBülent Ecevit UniversityZonguldakTurkey
  2. 2.College of Materials Science and Engineering, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, Nanshan District Key Lab for Biopolymers and Safety EvaluationShenzhen UniversityShenzhenChina

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