Journal of Porous Materials

, Volume 24, Issue 1, pp 257–265 | Cite as

Synthesis and characterization of magnetic mesoporous core–shell nanocomposites for targeted drug delivery applications

Article
First Online:
  • 384 Downloads

Abstract

Magnetic mesoporous nanocomposites are emerging as a significant new material to improve the effectiveness of cancer treatment and enhance the availability of drug therapy. Thus, the core–shell structure magnetic mesoporous nanocomposites (Fe3O4@SiO2@LDH) were synthesized with an average diameter of about 100 nm and used as methotrexate (MTX) carriers for cancer therapy. As an important biological material, Fe3O4@SiO2@LDH exhibited higher superparamagnetic behavior and biocompatibility, and the drugs can be loaded in the channels of the mesoporous silica and the interlayer of layered double hydroxides (LDH). The embedding rate of magnetic mesoporous silica (Fe3O4@SiO2) and LDH were 60.32 % and 0.67 %, respectively, and the release rate of the drug delivery systems (Fe3O4@SiO2@LDH-MTX) was 66.81 %. In addition, LDH as a kind of pH-sensitive material was adopted for controlled drug release and WST-1 assays in cancer cells (Hela) demonstrated that Fe3O4@SiO2@LDH-MTX presented high anti-tumor activity, while the carriers were nearly non-toxic. Therefore, all the results suggested that the magnetic nanocomposites can be employed to deliver MTX, and would be applied in the field of cancer therapy in the future.

Keywords

Magnetic nanocomposites Mesoporous silica pH-sensitive Cancer therapy 
This is a preview of subscription content, log in to check access.

Notes

Acknowledgments

The authors are grateful for National Science Foundation of China (No. 50972060), the Fundamental Research Funds for the Central Universities (No. 30920130112003) and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

References

  1. 1.
    M.C. Daniel, D. Astruc, Chem. Rev. 104, 293–346 (2004)CrossRefGoogle Scholar
  2. 2.
    E. Ruoslahti, S.N. Bhatia, M.J. Sailor, J. Cell. 188, 759–768 (2010)CrossRefGoogle Scholar
  3. 3.
    J. Wu, W. Jiang, S.S. Xu, Y.J. Wang, R. Tian, Sens. Actuators B: Chem. 211, 33–41 (2015)CrossRefGoogle Scholar
  4. 4.
    I.I. Slowing, J. Mater. Chem. 20, 7924–7937 (2010)CrossRefGoogle Scholar
  5. 5.
    S.S. Huang, C.X. Li, Z.Y. Cheng, Y. Fan, P.P. Yang, C.M. Zhang, K.Y. Yang, J. Lin, J. Colloid Interface Sci. 376, 312–321 (2012)CrossRefGoogle Scholar
  6. 6.
    X. Tian, Z. Dong, R. Wang, J. Ma, Sens. Actuators, B 183, 446–453 (2013)CrossRefGoogle Scholar
  7. 7.
    J. Wu, Y.J. Wang, W. Jiang, S.S. Xu, R.B. Tian, Appl. Surf. Sci. 321, 43–49 (2014)CrossRefGoogle Scholar
  8. 8.
    K.H. Shim, J. Hulme, E.H. Maeng, M.K. Kim, S.S. An, Int. J. Nanomed. 9, 207–215 (2014)CrossRefGoogle Scholar
  9. 9.
    J. Wang, R.R. Zhu, B. Gao, B. Wu, K. Li, X.Y. Sun, H. Liu, S.L. Wang, Biomaterials 35, 466–478 (2014)CrossRefGoogle Scholar
  10. 10.
    Y. Deng, D. Qi, C. Deng, X. Zhang, D. Zhao, JACS 130, 28–29 (2008)CrossRefGoogle Scholar
  11. 11.
    Q. Liu, J.X. Zhang, W. Sun, Q.R.B. Xie, W.L. Xia, H.C. Gu, Int. J. Nanomed. 7, 999–1013 (2012)Google Scholar
  12. 12.
    X. Guo, F. Mao, W. Wang, Y. Yang, Z. Bai, A.C.S. Appl, Mat. Interfaces 7, 14983–14991 (2015)CrossRefGoogle Scholar
  13. 13.
    J.L. Vivero-Escoto, I.I. Slowing, B.G. Trewyn, V.S.-Y. Lin, Small 6, 1952–1967 (2010)CrossRefGoogle Scholar
  14. 14.
    A.K. Gupta, M. Gupta, Biomaterials 26, 3995–4021 (2005)CrossRefGoogle Scholar
  15. 15.
    C.E. Myers, W.P. Mcguire, R.H. Liss, I. Ifrim, K. Grotzinger, R.C. Young, Science 197, 165–167 (1977)CrossRefGoogle Scholar
  16. 16.
    L.E. Gerweck, K. Seetharaman, Cancer Res. 56, 1194–1198 (1996)Google Scholar
  17. 17.
    J. Zhang, X. Li, J.M. Rosenholm, H.C. Gu, J. Colloid Interface Sci. 361, 16–24 (2011)CrossRefGoogle Scholar
  18. 18.
    Y. Chen, H.G. Chen, S.J. Zhang, F. Chen, L.X. Zhang, J.M. Zhang, M. Zhu, H.X. Wu, L.M. Guo, J.W. Feng, J.L. Shi, Adv. Funct. Mater. 21, 270–278 (2011)CrossRefGoogle Scholar
  19. 19.
    C.Y. Lai, B.G. Trewyn, D.M. Jeftinija, K. Jeftinija, S. Xu, S. Jeftinija, V.S. Lin, J. Am. Chem. Soc. 125, 4451–4459 (2003)CrossRefGoogle Scholar
  20. 20.
    K.M. Tyner, S.R. Schiffman, E.P. Giannelis, J. Control Release 95, 501–514 (2004)CrossRefGoogle Scholar
  21. 21.
    A. Tarnawski, R. Pai, R. Itani, F.A. Wyle, Digestion 60, 449–455 (1999)CrossRefGoogle Scholar
  22. 22.
    Z. Gu, A.C. Thomas, Z.P. Xu, J.H. Campbell, G.Q. Lu, Chem. Mater. 20, 3715–3722 (2008)CrossRefGoogle Scholar
  23. 23.
    J.H. Wang, S.R. Zheng, Y. Shao, J.L. Liu, Z.Y. Xu, J. Colloid Interface Sci. 349, 293–299 (2010)CrossRefGoogle Scholar
  24. 24.
    J. Wu, S.S. Xu, W. Jiang, Y. Shen, M. Pu, Biotechnol. Lett. 3, 585–591 (2015)CrossRefGoogle Scholar
  25. 25.
    J. Varshosaz, H. Sadeghi-aliabadi, S. Ghasemi, B. Behdadfar, Biomed. Res. Int. 2013, 1–16 (2013)Google Scholar

Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  1. 1.National Special Superfine Powder Engineering Research CenterNanjing University of Science and TechnologyNanjingChina

Personalised recommendations