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Controlled-release drug carriers based mesoporous silica spheres with hierarchical hollow/nano structure

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Abstract

Mesoporous silica spheres with hierarchical hollow/nano structure (MSSH-H/N) have been successfully prepared by a template-guided approach, in which cetyltrimethyl ammonium bromide (CTAB) and polystyrene (PS) emulsion was used as the template of mesopores and hollow core, respectively. A consecutive template mechanism and the formation of the hierarchical hollow/nano structure were proposed on basis of the combined characterizations including transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction patterns (XRD) and nitrogen sorption analysis, which showed that the hierarchical structure is composed of mesoporous hollow SiO2 spheres and discrete mesoporous SiO2 nanoparticles coating on the shell. Ibuprofen (IBU) was chosen as a drug model in delivery and release experiments, and these MSSH-H/N samples exhibited higher drug loading capacity, desired low initial IBU release rate and typical two-phase drug release behavior compared with conventional single-structure (single-shelled) hollow mesoporous silica spheres due to their unique hierarchical hollow/nano structure.

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Acknowledgments

This work was supported by National Natural Science Foundation of China (51472062, 21303031), Natural Science Foundation of Heilongjiang Province of China (B201010), Fundamental Research Funds for the Central Universities (HIT. IBRSEM. 201326) and Program for Science and Technology Innovation Talent in Harbin (2013RFQXJ004).

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Authors and Affiliations

  1. MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin, China

    Yifei Teng, Yanqiu Jiang, Xianzhu Xu & Kaifeng Lin

  2. Endocrinology and Genetics, Pediatrics Department, The First Bethune Hospital of Jilin University, Changchun, 130000, China

    Yining Zhang

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  1. Yifei Teng
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  2. Yanqiu Jiang
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  3. Yining Zhang
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Correspondence to Yanqiu Jiang or Kaifeng Lin.

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Teng, Y., Jiang, Y., Zhang, Y. et al. Controlled-release drug carriers based mesoporous silica spheres with hierarchical hollow/nano structure. J Porous Mater 24, 241–248 (2017). https://doi.org/10.1007/s10934-016-0257-1

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