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The Protein Journal

, Volume 38, Issue 5, pp 525–536 | Cite as

Structure and Function of an Inflammatory Cytokine, Interleukin-2, Analyzed Using the Bioinformatic Approach

  • Urmi RoyEmail author
Article

Abstract

The inflammatory cytokine, interleukin-2 (IL-2), is an important regulator of cellular functions. This relatively less studied member of the interleukin protein family is responsible for multiple immuno-modulatory and immuno-stimulatory tasks, like T cell activation, triggering of natural killer cells, inflammation, as well as proliferation and progression of autoimmune diseases and cancers. In this communication we report the temporally variant structural aspects of the IL-2 ligand and its receptor interfaces, based on the available crystal structures. The intended goal of this effort is to generate simulated results that could potentially aid the designs of novel structure based therapeutics.

Keywords

Biotechnology Bioinformatics Structural modeling Interleukin 2 Interleukin 2 receptor Signaling 

Abbreviations

aa

Amino acid

IL

Interleukin

IL-2

Interleukin-2

IL-2R

Interleukin-2 receptor

MD

Molecular dynamics

PDB

Protein Data Bank

RMSD

Root mean square deviation

RMSF

Root mean square fluctuation

TH

T helper

Notes

Acknowledgements

The author acknowledges utilization of the following simulation and visualization software packages: (1) NAMD and (2) VMD: NAMD and VMD, developed by the Theoretical and Computational Biophysics Group in the Beckman Institute for Advanced Science and Technology at the University of Illinois, Urbana-Champaign. (3) Discovery Studio Visualizer: Discovery Studio Modeling Environment, Release 3.5, Accelrys Software Inc., San Diego, 2012.

Compliance with Ethical Standards

Conflict of interest

The author declares no conflict of interest.

Supplementary material

10930_2019_9833_MOESM1_ESM.pdf (1.1 mb)
Supplementary material 1 (PDF 1107 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Chemistry & Biomolecular ScienceClarkson UniversityPotsdamUSA

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