Discussion on Patients with Bipolar Disorder and Depressive Episode by Ratio Low Frequency Amplitude Combined with Grey Matter Volume Analysis

  • Xiaohong Wang
  • Na Zhao
  • Jingjing Shi
  • Yuhua Wu
  • Jun Liu
  • Qiang Xiao
  • Jian HuEmail author
Image & Signal Processing
Part of the following topical collections:
  1. Artificial Intelligence Application in Health Informatics


In order to explore the brain functional and structural imaging results of patients with bipolar disorder and depressive episode without taking medicine, and to further explore the disease mechanism of bipolar disorder by combining with clinical symptoms and cognitive function (neuropsychological test), DPABI (Data Processing and Analysis (Resting-State) For Brain Image) software is used to pre-process fMRI (functional magnetic resonance imaging) data and calculate fALFF (ratio low frequency fluctuation amplitude) index. In addition, SPM8 is applied for grey matter volume analysis based on voxel morphology. Pearson correlation model is used to analyze the relationship between functional and morphological changes and clinical symptoms and cognitive tests. DPABI software and SPSS 22.0 software are used to analyze the data. The results show that corresponding abnormal brain areas are found in both functional and structural aspects of patients with bipolar disorder and depression, involving LCSPT emotional circuits. More importantly, the superior frontal gyrus shows significant abnormalities in both functional and structural analysis.


biphasic disorder resting-state fMRI fALFF grey matter volume analysis 


Compliance with Ethical Standards

Conflict of Interest

Author Xiaohong Wang declares that he has no conflict of interest. Author Na Zhao declares that he has no conflict of interest. Author Jingjing Shi declares that he has no conflict of interest. Author Yuhua Wu declares that he has no conflict of interest. Author Jun Liu declares that he has no conflict of interest. Author Qiang Xiao declares that he has no conflict of interest. Author Jian Hu declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

This article does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all individual participants included in the study.


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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Xiaohong Wang
    • 1
  • Na Zhao
    • 1
  • Jingjing Shi
    • 2
  • Yuhua Wu
    • 2
  • Jun Liu
    • 2
  • Qiang Xiao
    • 3
  • Jian Hu
    • 1
    Email author
  1. 1.Department of PsychiatryThe First Affiliated Hospital of Harbin Medical UniversityHarbinChina
  2. 2.The First Specialized Hospital of HarbinHarbinChina
  3. 3.Department of RadiologyThe First Specialized Hospital of HarbinHarbinChina

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