Journal of Mammary Gland Biology and Neoplasia

, Volume 16, Issue 4, pp 421–432

Gene Polymorphisms: The Keys for Marker Assisted Selection and Unraveling Core Regulatory Pathways for Mastitis Resistance



One of the most frequent mammary diseases impacting lactating animals is mastitis, an inflammation of the mammary gland most commonly caused by bacterial infection. The severity of mastitis is greatly influenced by the invading organism and the subsequent immune response which must recognize the foreign organism, recruit immune cells, eliminate the invading pathogen, and resolve the inflammatory response. The speed, strength, and duration of this response and subsequent disease susceptibility are critically tied to the genetic background of an animal. However, the genetic contribution has been difficult to identify due to the complex interactions that must occur for effective disease resistance. Recent studies have utilized polymorphisms to better define the genes and chromosomal regions that contribute to mastitis resistance. This review will examine these studies with primary emphasis in bovine systems, as the most work regarding mastitis has been conducted in this species.


SNP QTL Dairy Mastitis Immunity 



single nucleotide polymorphism


quantitative trait loci


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Animal ScienceThe University of TennesseeKnoxvilleUSA
  2. 2.Department of Veterinary PathobiologyUniversity of MissouriColumbiaUSA

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