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Crosstalk of TGF-β and Estrogen Receptor Signaling in Breast Cancer

  • Arja M. Band
  • Marikki Laiho
Article

Abstract

Estrogen receptor-α (ERα) and transforming growth factor (TGF)-β signaling pathways are major regulators during mammary gland development, function and tumorigenesis. Predominantly, they have opposing roles in proliferation and apoptosis. While ERα signaling supports growth and differentiation and is antiapoptotic, mammary gland epithelia cells are very sensitive to TGF-β—induced cell cycle arrest and apoptosis. Their regulatory pathways intersect, and ERα blocks TGF-β pathway by multiple means, including direct interactions of its signaling components, Smads. However, relatively little is known of the dysfunction of their interactions in cancer. A better understanding would help to develop new strategies for breast cancer treatment.

Keywords

Estrogen receptor TGF-β signaling Breast cancer Smad SnoN 

Abbreviations

AF

Activation function

EMT

Epithelial-to-mesenchymal transition

ERα

Estrogen receptor-α

ERβ

Estrogen receptor-β

HAT

Histone acetyltransferase

HDAC

Histone deacetylase

MAPK

Mitogen activated protein kinase

PI3K

Phosphatidylinositol 3-OH kinase

R-Smad

Receptor regulated Smad

SnoN

Ski-related novel gene

TAM

Tamoxifen

TGF-β

Transforming growth factor-β

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Molecular Cancer Biology Program, Biomedicum Helsinki and Haartman InstituteUniversity of HelsinkiHelsinkiFinland
  2. 2.Sidney Kimmel Comprehensive Cancer CenterThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Department of Radiation Oncology and Molecular Radiation SciencesThe Johns Hopkins University School of MedicineBaltimoreUSA

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