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The Role of Endocrine Insulin-Like Growth Factor-I and Insulin in Breast Cancer

  • Danielle Lann
  • Derek LeRoith
Article

Abstract

Epidemiologic studies demonstrate that breast cancer is the most common type of cancer diagnosed in women and is a significant cause of morbidity and mortality. While there are many risk factors known to be associated with increased breast cancer risk, this review will focus specifically on circulating IGF-I, hyperinsulinemia, and type 2 diabetes. Their effects on promoting breast cancer development, progression, and adverse outcomes have been demonstrated in both animal and human studies, suggesting that the IGF system is a potential target for breast cancer therapy. In addition, in the clinical setting, emphasizing metabolic risk modifications to patients including weight loss, dietary changes, and diabetes control may also play an important role in breast cancer risk reduction.

Keywords

Insulin-like growth factor IGF-I Insulin Hyperinsulinemia Insulin resistance Diabetes Breast cancer 

Abbreviations

IGF

insulin-like growth factor

IGFBP

insulin-like growth factor binding protein

BMI

body mass index

IGF-IR

insulin-like growth factor-I receptor

IR

insulin receptor

IRS

insulin receptor substrate

PI3K

phosphatidylinositol 3-kinase

MAPK

mitogen-activated protein kinase

ER

estrogen receptor

TEB

terminal end bud

GH

growth hormone

GHRH

growth hormone releasing hormone

JAK

janus kinase

STAT

signal transducer and activator of transcription

ALS

acid labile subunit

MMTV

mouse mammary tumor virus

SDR

spontaneous dwarf rat

LID

Liver IGF-I Deficient

DMBA

7,12-dimethylbenz(a)anthracene

SV40-LTA

SV40 large T antigen

SHBG

sex hormone binding globulin

MCK

muscle creatine kinase

PyVmT

polyoma virus middle T antigen

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© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Division of Endocrinology, Diabetes, and Bone Diseases, Department of MedicineMount Sinai School of MedicineNew YorkUSA

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