Journal of Mammary Gland Biology and Neoplasia

, Volume 13, Issue 3, pp 323–335 | Cite as

Signal Transduction in Transgenic Mouse Models of Human Breast Cancer—Implications for Human Breast Cancer

Article

Abstract

The advent of genetically engineered mouse models (GEMs) of human breast cancer, have provided important insight into molecular basis or human breast cancer. This review will focus on two of the most extensively studied mouse models for human breast cancer involving mammary gland specific expression of the polyoma middle T (PyV MT) antigen and of the ErbB2. In addition, this review will discuss past and recent advances in understanding relative contribution of the signaling pathways in tumor induction and metastasis by these potent mammary oncogenes.

Keywords

ErbB2 PyV MT Transgenic MMTV Breast cancer 

Abbreviations

CKI

cyclin kinase inhibitors

DCIS

ductal carcinoma in situ

ECM

extracellular matrix

EGFR

epidermal growth factor receptor

EMT

epithelial to mesenchymal transition

ERα

estrogen receptor α

FAK

focal adhesion kinase

GEM

genetically-engineered mouse

IGF-1R

insulin-like growth factor-1 receptor

IKK

IκB kinase

IR

insulin receptor

IRS

insulin receptor substrates

LOH

loss of heterozygosity

MMP

matrix metalloproteinases

MMTV

mouse mammary tumor virus

PTP1B

protein tyrosine phosphatase 1B

PyV MT

polyoma middle T

RCAS

replication-competent avian leukosis virus long terminal repeat with splice acceptor

TGF-β

transforming growth factor-β

TβRII

TGF-β type II receptor

TIMP

tissue inhibitors of metalloproteinases

uPa

urokinase-type plasminogen activator

VEGF-R

vascular endothelial growth factor receptor

WAP

whey acidic protein

Wip

wildtype p53-induced phosphatase 1

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Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  1. 1.Molecular Oncology GroupRoyal Victoria HospitalMontrealCanada
  2. 2.Department of BiochemistryMcGill UniversityMontrealCanada
  3. 3.Department of MedicineMcGill UniversityMontrealCanada

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