Journal of Mammary Gland Biology and Neoplasia

, Volume 12, Issue 2–3, pp 163–173 | Cite as

Hedgehog Signaling in Mammary Gland Development and Breast Cancer

Article

Abstract

The Hedgehog pathway is critical for many developmental processes, including the formation of several epidermal appendages. In the mammary gland strict regulation of the Hedgehog pathway is required for normal development. Alterations in Hedgehog signaling result in defects in both the embryonic and postnatal mammary gland. Activation of Hedgehog signaling either by mutation or misexpression of pathway members can lead to the development and/or progression of cancers in multiple organs. This review addresses the current understanding and controversies of Hedgehog signaling in mammary gland development and its potential role in promoting breast carcinogenesis and cancer progression.

Keywords

Breast Cancer Mammary gland Development Hedgehog Patched Gli1 Gli2 Gli3 

Abbreviations

Casein kinase 1 alpha

CK1α

Cubitus interruptus

Ci

Desert hedgehog

Dhh

Epithelial to mesenchymal transition

EMT

Fibroblast growth factor

Fgf

Glycogen synthase kinase 3β

GSK3β

Growth arrest specific gene

Gas1

Hedgehog

Hh

Hedgehog interacting protein

Hip

Indian hedgehog

Ihh

Intraflagellar transport

IFT

Patched

Ptch

Protein kinase A

PKA

Smoothened

Smo

Sonic hedgehog

Shh

Suppressor of fused

Sufu

Terminal end buds

TEBs

Notes

Acknowledgements

Research in Dr. Andra Frost’s lab is supported by the American Cancer Society (RSG-05-207-01-TBE) and the NIH (CA97472 and CA105950). Dr. Sarah Hatsell’s work is supported by the Susan G. Komen Foundation and Philip Morris USA Inc. and by Philip Morris International. Appreciation is extended to Dr. Michael T. Lewis for thoughtful discussion and sharing of data during the writing of this manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Department of Cell BiologyNew York University School of MedicineNew YorkUSA
  2. 2.Department of PathologyUniversity of Alabama at BirminghamBirminghamUSA
  3. 3.Wallace Tumor InstituteUniversity of Alabama at BirminghamBirminghamUSA

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