Preclinical Imaging of Mammary Intraepithelial Neoplasia with Positron Emission Tomography

  • Craig K. Abbey
  • Alexander D. Borowsky
  • Jeffery P. Gregg
  • Robert D. Cardiff
  • Simon R. Cherry


Small-animal imaging with positron emission tomography (PET) has become a valuable tool for evaluating preclinical models of breast cancer and other diseases. In this review, we examine a number of issues related to preclinical imaging studies with PET, using transgenic models of ductal carcinoma in situ and metastasis as specific examples. We discuss imaging components such as reconstruction, normalization, and extraction of quantitative parameters. We also analyze the effect of longitudinal correlations on cohort size and present some simple statistical techniques for determining cohort sizes that may be helpful in designing preclinical imaging studies. We describe studies that are greatly facilitated by access to non-invasive imaging data including a study involving multiple endpoints and another investigating metastasis. We conclude with a brief survey of emerging approaches in small-animal PET imaging.


Positron emission tomography Preclinical imaging Mammary intraepithelial neoplasia Therapeutic response 



filtered backprojection




maximum a posteriori


mammary intraepithelial neoplasia-outgrowth


maximum intensity projection


positron emission tomography


Polyoma Virus middle-T


region of interest


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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Craig K. Abbey
    • 1
    • 2
  • Alexander D. Borowsky
    • 3
    • 4
  • Jeffery P. Gregg
    • 3
    • 4
  • Robert D. Cardiff
    • 3
    • 4
  • Simon R. Cherry
    • 1
  1. 1.Department of Biomedical EngineeringUniversity of CaliforniaDavisUSA
  2. 2.Department of PsychologyUniversity of CaliforniaSanta BarbaraUSA
  3. 3.Department of Pathology and Laboratory Medicine, School of MedicineUniversity of CaliforniaDavisUSA
  4. 4.Center for Comparative MedicineUniversity of CaliforniaDavisUSA

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