Inhibitors of Insulin-like Growth Factor Signaling: A Therapeutic Approach for Breast Cancer



The peptide growth factors IGF-I and IGF-II not only play a role in the development of the mammary gland but are also implicated in breast cancer. Several reagents disrupting IGF signaling have been developed and clinical trials validating IGF signaling as a target in cancer therapy are underway. This review highlights the approaches to inhibiting IGF signaling in breast cancer.


Insulin-like growth factors Type I IGF receptor Breast cancer Targeted therapy Antibodies Small molecule inhibitors 



antibody-dependent cellular cytotoxicity


aromatase inhibitor


eukaryotic translation initiation factor 4E


eukaryotic translation initiation factor 4E binding protein 1


estrogen receptor


growth hormone


growth hormone-releasing hormone


insulin-like growth factor


IGF binding proteins


type I IGF receptor


insulin receptor


insulin receptor substrate


mitogen-activated protein kinase


mouse mammary tumor virus


mammalian target of rapamycin


phosphatidylinositol 3′ kinase


protein kinase B


phosphotyrosine binding


selective estrogen receptor modulator


Src-homology 2


small interference RNA


whey acidic protein


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  1. 1.Department of Medicine and Cancer CenterUniversity of MinnesotaMinneapolisUSA

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