The Role of the Epidermal Growth Factor Receptor in Breast Cancer

  • Samuel K. Chan
  • Mark E. Hill
  • William J. GullickEmail author


Recent trials of drug therapy targeting the erbB receptor HER2 have met with success in breast cancer. The epidermal growth factor receptor or EGFR is a closely related receptor from this same family that is involved in cellular signal transduction and tumor cell growth and survival. Emerging evidence indicates that EGFR is implicated in the development of hormone-resistant breast cancer, and that its activity is intertwined with estrogen receptor. Here, the role of EGFR in breast cancer is reviewed, and data from selected clinical trials of signal transduction inhibition of this cellular target are summarized.


Breast ErbB EGFR Signal transduction Hormone resistance Gefitinib Erlotinib 



human epidermal growth factor receptor


epidermal growth factor receptor


estrogen receptor


progesterone receptor


phosphorylated mitogen activated protein kinase


type 3 variant of EGFR


adenosine triphosphate


insulin growth factor 1 receptor


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Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Samuel K. Chan
    • 1
    • 2
  • Mark E. Hill
    • 2
  • William J. Gullick
    • 1
    Email author
  1. 1.Cancer Biology LaboratoryResearch School of Biosciences, University of KentCanterburyUK
  2. 2.Kent Oncology CentreMaidstoneUK

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