Journal of Mammary Gland Biology and Neoplasia

, Volume 11, Issue 1, pp 3–11

The Role of the Epidermal Growth Factor Receptor in Breast Cancer

  • Samuel K. Chan
  • Mark E. Hill
  • William J. Gullick
Article
  • 166 Downloads

Abstract

Recent trials of drug therapy targeting the erbB receptor HER2 have met with success in breast cancer. The epidermal growth factor receptor or EGFR is a closely related receptor from this same family that is involved in cellular signal transduction and tumor cell growth and survival. Emerging evidence indicates that EGFR is implicated in the development of hormone-resistant breast cancer, and that its activity is intertwined with estrogen receptor. Here, the role of EGFR in breast cancer is reviewed, and data from selected clinical trials of signal transduction inhibition of this cellular target are summarized.

Keywords

Breast ErbB EGFR Signal transduction Hormone resistance Gefitinib Erlotinib 

Abbreviations

HER

human epidermal growth factor receptor

EGFR

epidermal growth factor receptor

ER

estrogen receptor

PR

progesterone receptor

pMAPK

phosphorylated mitogen activated protein kinase

EGFRvIII

type 3 variant of EGFR

ATP

adenosine triphosphate

IGF1-R

insulin growth factor 1 receptor

Copyright information

© Springer Science + Business Media, Inc. 2006

Authors and Affiliations

  • Samuel K. Chan
    • 1
    • 2
  • Mark E. Hill
    • 2
  • William J. Gullick
    • 1
  1. 1.Cancer Biology LaboratoryResearch School of Biosciences, University of KentCanterburyUK
  2. 2.Kent Oncology CentreMaidstoneUK

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