Introduction on Angiogenesis in Breast Cancer
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Angiogenesis is a complex process involving the growth and organization of blood vessels, and has been studied for over 30 years. Many excellent reviews about the distinct events that lead to the production of a vascular and microvascular tree exist already. Of course, much of the work has been focused on the angiogenesis present in pathologic states, notably oncogenesis and inflammatory diseases.
Starting with the original work of Paget and then continued by many other researchers spearheaded by the original and groundbreaking work of Judah Folkman, Josh Fidler, and Mina Bissell, studies of abnormal angiogenesis have focused on understanding the complex interactions between the supporting stroma and the “diseased” index cell. In particular, a growing concern about tissue-specific signals has raised awareness that although governed by common principles, the details of abnormal angiogenesis require models that realistically reflect the intricacies of tissue specificity. We believe that...