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Journal of Mathematical Chemistry

, Volume 56, Issue 5, pp 1365–1392 | Cite as

Design formalism for DNA self-assembly of polyhedral skeletons using rigid tiles

  • Margherita Maria Ferrari
  • Anna Cook
  • Alana Houlihan
  • Rebecca Rouleau
  • Nadrian C. Seeman
  • Greta Pangborn
  • Joanna Ellis-Monaghan
Original Paper
  • 252 Downloads

Abstract

We describe the half-lap model, a mathematical framework that captures the geometric constraints of rigid tiles that are branched junction molecules used as building blocks for tile-based DNA self-assembly. The model captures not only the combinatorial structures of the sets of cohesive ends on the tiles, but also the specific geometry of the inter-arm angles of the tiles and most critically the relative orientations of adhering tiles. We illustrate the functionality of the model by providing provably optimal DNA self-assembly strategies to construct Platonic and Archimedean 3-regular polyhedral skeletons and computing the minimum number of tile types and bond-edge types for each target structure. We further demonstrate the utility of the model by using it to analyze the benefits and limitations of palindromic rigid tiles. Moreover, we give explicit combinatorial and geometric descriptions of the tiles needed for each construction.

Keywords

DNA self-assembly strategies Rigid branched tiles Tile types Bond-edge types Platonic and Archimedean solids 

Notes

Acknowledgements

The work of Joanna Ellis-Monaghan, Greta Pangborn, and Nadrian C. Seeman was supported by the National Science Foundation (NSF) under Grant DMS-1332411.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of MathematicsPolitecnico di MilanoMilanoItaly
  2. 2.Department of EnglishSaint Michael’s CollegeColchesterUSA
  3. 3.Department of MathematicsSaint Michael’s CollegeColchesterUSA
  4. 4.Department of ChemistryNew York UniversityNew YorkUSA
  5. 5.Department of Computer ScienceSaint Michael’s CollegeColchesterUSA

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