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Journal of Mathematical Chemistry

, Volume 50, Issue 10, pp 2689–2702 | Cite as

On characterizing proteomics maps by using weighted Voronoi maps

  • Rok Orel
  • Milan Randić
Original Paper

Abstract

In contrast to the standard construction of Voronoi regions, in which the boundaries between different regions are at equal distance from the given points, we consider the construction of modified Voronoi regions obtained by giving greater weights to spots reported to have higher abundance. Specifically we are interested in applying this approach to 2-D proteomics maps and their numerical characterization. As will be seen, the boundaries of the weighted Voronoi regions are sensitive to the relative abundances of the protein spots and thus the abundances of protein spots, the z component of the (x, y, z) triplet, are automatically incorporated in the numerical analysis of the adjacency matrix, rather than used to augment the adjacency matrix as non-zero diagonal matrix elements. The outlined approach is general and it may be of interest for numerical analyses of other maps that are defined by triplets (x, y, z) as input information.

Keywords

Proteomics maps Voronoi regions LY171833 peroxisome proliferator Weighted Voronoi regions 

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.XLABLjubljanaSlovenia
  2. 2.National Institute of ChemistryLjubljanaSlovenia

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